Inhibition lymphocyte migration, effect

Steroids appear to have an effect on nearly every aspect of the immime system They inhibit both migration of neutrophils into the extracellular space and their adherence to the vascular endothelium at the site of tissue injury. In therapeutic dosages steroids also inhibit macrophage access to the site of inflammation, interfere with lymphocyte activity, and decrease the number of B andT lymphocytes. 

Pterodon polygalaeflorus (Benth.) (Eabaceae) EO was investigated for its anti-in ammatory effects with the air pouch model. The EO reduced acute in ammatory symptoms and inhibited lymphocyte proliferation. It also diminished neutrophil migration to the in amed tissue (Velozo et al, 2013). 

Corticosteroids are very effective for the treatment of allergic rhinitis. Efficacy is related to anti-inflammatory activities including the following decreased nasal eosinophil, basophil, and goblet ceUs, decreased mucosal mast cells, inhibition of leukocyte influx into the nasal cavity, inhibition of lymphocyte migration and cytokine release, and inhibition of late-phase allergic response (72,73). 

The opioids modulate the immune system by effects on lymphocyte proliferation, antibody production, and chemotaxis. In addition, leucocytes migrate to the site of tissue injury and release opioid peptides, which in turn help counter inflammatory pain. However, natural killer cell cytolytic activity and lymphocyte proliferative responses to mitogens are usually inhibited by opioids. Although the mechanisms involved are complex, activation of central opioid receptors could... 

Anti-inflammatory effects Glucocorticoids have a dramatic effect on the distribution and function of leukocytes. These drugs increase neutrophils and decrease lymphocytes, eosinophils, basophils, and monocytes. The migration of leukocytes is also inhibited. The biochemical mechanisms underlying these cellular effects include the induced synthesis of an inhibitor of phospholipase A2 (see Chapter 18), decreased mRNA for COX-2, decreases in IL2 and IL3, ind decreases in platelet activating factor (PAF), an inflammatory cytokine. 

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