Infrared spectroscopy chemical imaging

Later chapters detail application of the present method to electron spectroscopy for chemical analysis (Chapter 5), high-resolution dispersive infrared spectroscopy (Chapter 6), and tunable-diode-laser spectroscopy (Chapter 7). Because the heart of the method is the repeated application of simple convolution, the method has been adapted to the processing of images (Kawata et al, 1978 Kawata and Ichioka, 1980a Saghri and Tescher, 1980 Maitre, 1981 Gindi, 1981). 

FIGURE 13 Interrelation between design space, PAT, and process control in a manufacturing system based on quality-by-design. (Source R. C. Lyon, Process monitoring of pilot-scale pharmaceutical blends by near-infrared chemical imaging and spectroscopy, Eastern Analytical Symposium (EAS), Somerset, NJ, 2006.)... 

Lewis, E. N., Lee, E., and Kidder, L. H. (2004), Combining imaging and spectroscopy Solving problems with near infrared chemical imaging, Microscopy Today, 12, 8-12. 

Near-infrared chemical imaging instrumentation is rugged and flexible, suitable for both the laboratory and the manufacturing environment. Therefore analysis methods developed in the laboratory can often be tailored for implementation near-line or at-line. NIR-CI is also a massively parallel approach to NIR spectroscopy, making the technique well suited for high-throughput applications. 

Near-infrared chemical imaging using multichannel detectors inherits many of the attributes of conventional NIR spectroscopy using a single-channel detector. In addition to its well-documented capabilities as a spectroscopic technique, in comparison to other vibrational imaging approaches, it has unparalleled flexibility in terms of managing widely varying sample size, placement, shape and color. As has been shown with the three examples presented in this chapter, the technique easily... 

Taylor, S. K. and McClure, W. F. (1990) NIR imaging spectroscopy measuring the distribution of chemical components. In Near Infrared Spectroscopy (M. Iwamoto and S. Kawano, eds), Korin Publishing Co. Ltd., Japan, pp. 393 104. 

Treado, P. J., Levin, I. W. and Lewis, E. N. (1992) Near-infrared acousto-optic filtered spectroscopy a solid state approach to chemical imaging, Appl. Spectrosc. 46, 553-9. 

Bonino brought forward a further contribution to the theory of infrared spectra of organic liquids by incorporating the Bohr-Sommerfeld quantum conditions, including the correspondence principle of Bohr as well. This paved the way toward establishing a correlation between the physical and chemical image of molecules in the study of infrared spectra. From this series of papers on infrared spectroscopy, one can already observe the interdisciplinary character of Bonino s thought. In a lecture delivered some years later, Bonino offered these reflections on his chosen field of research ... 

Small, V. Fritz, A. Wetzel, D. (2006). Chemical imaging of intact seeds with NIR focal plane array assists plant hreeding. Vibrational Spectroscopy Vol.42, N.2, pp. 215-221 Sorensen, L.K. (2009). Application of reflectance near infrared spectroscopy for bread analyses. Food Chemistry Vol.113, pp. 1318-1322 Stark, E.K. Luchter, K. (2003). Diversity in NIR Instrumentation, in Near Infrared Spectroscopy. Proceeding oh the 11th International Conference. NIR Publication, Chichester, UK, pp. 55-66... 

TLC remains one of the most widely used techniques for a simple and rapid qualitative separation. The combination of TLC with spectroscopic detection techniques, such as FTIR or nuclear magnetic resonance (NMR), is a very attractive approach to analyze polymer additives. Infrared microscopy is a powerful technique that combines the imaging capabUities of optical microscopy with the chemical analysis abilities of infrared spectroscopy. FTIR microscopy allows obtaining of infrared spectra from microsized samples. Offline TLC-FTIR microscopy was used to analyze a variety of commercial antioxidants and light stabilizers. Transferring operation and identification procedure by FTIR takes about 20 min. However, the main drawbacks of TLC-FTIR are that TLC is a time-consuming technique and usually needs solvent mixtures, which makes TLC environmentally unsound, analytes must be transferred for FTIR analysis, and TLC-FTIR cannot be used for quantifying purposes. 

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