Information paradigm

Supramolecular Chemistry - From the Lock-and-Key Image to the Information Paradigm, 1, 307. 

Lehn J-M (1994) Perspectives in supramolecular chemistry from the lock-and-key image to the information paradigm. In Behr JP (ed) Perspectives in supramolecular chemistry, vol 1. The lock-and-key principle. The state of the art - 100 years on. Wiley, Chichester, p 307... 

From Condensed Matter to Organized Matter. The Information Paradigm... 

The fluid mechanics origins of shock-compression science are reflected in the early literature, which builds upon fluid mechanics concepts and is more concerned with basic issues of wave propagation than solid state materials properties. Indeed, mechanical wave measurements, upon which much of shock-compression science is built, give no direct information on defects. This fluids bias has led to a situation in which there appears to be no published terse description of shock-compressed solids comparable to Kormer s for the perfect lattice. Davison and Graham described the situation as an elastic fluid approximation. A description of shock-compressed solids in terms of the benign shock paradigm might perhaps be stated as ... 

Though there was of course no way for Zuse to answer his second question (nor is there any way today), the fact that it is being asked at all underscores the essence of the second of the two paradigm shifts listed earlier in this chapter the notion that information is more fundamental than what have traditionally been used as fundamental variables (mass, energy, etc.). Zuse suggests that if only we could find an appropriate language or formalism with which to describe this primordial information, we would find, for example, that the information content of two or more interacting particles is conserved. 

Text mining is the bread-and-butter method used by researchers on a daily basis [31, 32]. If you ask researchers what they really want from information management, you might be surprised how often they wish for a science Google to mine for data. As beautiful and simple as this paradigm sounds. 

Chemical structural information is one of the missing pieces in the great effort to bring biomedical research into the realm of twenty-first century information extraction and knowledge discovery paradigms. Proteins, genes, diseases, and chemical compounds constitute the major entities extracted in the biomedical domain. The ability to read structure information and substructure information and their association to other entities could have a major impact on toxicity information in particular and ADMET data in general. 

Chapman, K., Challenges, transitions, and paradigm shifts for information technology, Pharm. Technol., 19, 120, 1995. 

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