Influence of dissolution

E. Nelson, Influence of dissolution rate and surface on tetracycline absorption, J. Am. Pharm. Assoc. Sci. Ed., 48, 96-103 (1959). 

Sandberg, A., Abrahamsson, B., Sjogren, J., Influence of dissolution rate on the extent and rate of bioavailability of metoprolol, Int. J. 

Costa P, Sousa Lobo JM. Influence of dissolution medium agitation on release profiles of sustained-release tablets. Drug Dev Ind Pharm 2001 27 811-817. 

A number of experimental and theoretical studies analyzed the influence of dissolution processes on the physical and chemical properties of soluble porous matrices (Fogler and Rege 1986 Daccord and Lenormand 1987 Hoefner and Fogler 1988 Daccord 1987 Daccord et al. 1993). Similarly, several theoretical... 

The main aim of this section is to illustrate the influence of dissolution on layer-growth kinetics. Therefore, for each pair of initial substances, experiments with saturated and non-saturated melts will be described. 

To show the influence of dissolution of the Fe-Ni or Fe-Cr alloy base into liquid aluminium on the layer formation, two sets of experiments were... 

Influence of dissolution rate of lithium tablets on side effects... 

Plaque is an essential prerequisite for dental caries to occur, since it is plaque bacteria that produce the acid which dissolves the enamel. However, plaques are of varying cariogenicity, which depends to a large extent on their bacterial composition. In addition, plaque thickness should affect cariogenicity because thickness determines the extent of any acid challenge to the teeth [71, 72], Increasing plaque thickness would also be expected to minimise the potentially protective influence of dissolution inhibitors in saliva. 

Bonferoni, M.C., Rossi, S., Ferrari, F., Stavik, E., Pena-Romero, A. and CarameUa, C. (2000) Factorial analysis of the influence of dissolution medium on drug release from carrageenan-diltiazem complexes. AAPS PharmSciTech, 1, E15. 

M Bisrat, C Nystrom. P Edman, Influence of dissolution rate of sparingly soluble drugs on comeal permeability in vitro. Ini J Pharm 63 49-56, 1990. 

The main conclusion of Paciejewska s thesis is the necessity to consider the specific kinetics of interfacial phenomena when evaluating the stability of colloidal suspensions. This applies not only to binary, but to all kinds of colloidal suspensions. A major factor is the dissolution of the dispersed phase(s)—in particular if the solubility and the intrinsic dissolution rate are relatively large. Its relevance is especially pronounced for a large total surface area, which depends on the particle concentration and the specific surface of the particles and which determines the amount of substance that can be dissolved in a given period of time. For many nanoparticle (x < 100 nm) systems (e.g. additives for paints and coatings), it will not be permissible to ignore the influence of dissolution on the interfacial properties and even on suspension stability—independent from the Gibbs-Thomson effect, which becomes relevant at particle sizes below 10 nm (cf. Sect. 3.1.4). 

Studies of aqueous systems using the sealed thick-walled capsules do not provide any information about the pressure. The influence of dissolution of the capsule wall on die composition and properties of the system under study is another complicated problem. 

---