Influence diagnostics examples

Similar to the linear regression case, influence diagnostics for linear mixed models can be developed using case deletion. These extensions include Cook s distance, DFFITs, COVRATIO, and PRESS residuals. For example, a linear mixed effects extension to DFFITS is... 

Available space is insufficient to permit demonstrating the partial plots for the example. However, Table 9 lists the leverages and the four influence diagnostics associated with individual observations... 

There has been some suggestion that the DSM may be influenced by the development of other classification systems, most notably by the International Classification of Diseases (ICD-10 World Health Organization, 1992) which is a widely used international diagnostic system. There are certainly examples in the DSM-III-R and DSM-IV (American Psychiatric Association, 1987, 1994) that clearly indicate that the DSM was changed simply to make it more compatible with an ICD diagnosis. For example, the DSM-IV added a new diagnosis termed Acute Stress Disorder for compatibility with the ICD-10 (American Psychiatric Association, 1994, p. 783). 

Clinical utility takes the concept a step further and shows that the patient s medical outcome is favorably influenced by knowledge of the diagnostic test. An example would be that the tight insulin control that is only possible with frequent home blood glucose monitoring has a positive impact on delay of complications of diabetes. FDA does not require that a demonstration of clinical utility be performed in support of submissions but does... 

The contents of the present contribution may be outlined as follows. Section 6.2.2 introduces the basic principles of coupled heat and mass transfer and chemical reaction. Section 6.2.3 covers the classical mathematical treatment of the problem by example of simple reactions and some of the analytical solutions which can be derived for different experimental situations. Section 6.2.4 is devoted to the point that heat and mass transfer may alter the characteristic dependence of the overall reaction rate on the operating conditions. Section 6.2.S contains a collection of useful diagnostic criteria available to estimate the influence of transport effects on the apparent kinetics of single reactions. Section 6.2.6 deals with the effects of heat and mass transfer on the selectivity of basic types of multiple reactions. Finally, Section 6.2.7 focuses on a practical example, namely the control of selectivity by utilizing mass transfer effects in zeolite catalyzed reactions. 

Diagnostic tests may be rather useless, if the test result does not lead to any consequences, for example vdien no effective treatment is available or because the test procedure takes too long to influence the choice of therapeutic options. 

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