Inflammatory response neutrophils linked

Administration of erythrocytes can cause neutrophil priming, which leads to a dysfunctional inflammatory response. This neutrophil priming, which has been associated with the occurrence of multiple organ failure after trauma, was not observed after administration of Polyheme, a glutaraldehyde-cross-linked hemoglobin prodnct (3). 

Dendritic cells play a central role in the initiation of the irmate and adaptive immune response, and it is believed that they provide a link between them (32). The airways and lungs contain a rich network of dendritic cells that are localized near the surface, so that they are located ideally to signal the entry of foreign substances that are inhaled. Dendritic cells can activate a variety of other inflammatory and immune cells, which include macrophages and neutrophils, as well as T- and B-Iymphocytes, so dendritic cells may play an important role in the pulmonary response to cigarette smoke and other inhaled noxious agents. However, an increase in dendritic cells is not observed in the airways of COPD patients in contrast to asthma patients (33)... 

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