Induction of lipoxygenase

Bohland, C., Balkenhohl, T., Loers, G. et al. 1997. Differential induction of lipoxygenase isoforms in wheat upon treatment with rust fungus elicitor, chitin oligosaccharides, Chitosan, and Methyl Jasmonate. Plant Physiol. 114(2) 679-685. 

Table 2 Induction of lipoxygenases in higher plants by pathogen infection ...

Barley leaf segments respond to the application of (-)-jasmonic acid (JA) or its methylester (JM) as well as to several stress conditions like osmotic stress with the synthesis of so called jasmonate induced proteins (JIPs). Among these proteins is a thionin of 6 kDa, and a protein of 23 kDa with yet unknown function [1]. Beside these results we present evidence on the specific induction of lipoxygenase (LOX) forms in barley leaf segments by jasmonate or by osmotic stress conditions, like incubation with 1 M sorbitol. 

Williams, JH and Bliss, TV (1989) An in vitro study of the effect of lipoxygenase and cyclooxygenase inhibitors of arachidonic acid on the induction and maintenance of long-term potentiation in the hippocampus. Neurosci. Lett. 107 301-309. 

It is possible that dietary flavonoids participate in the regulation of cellular function independent of their antioxidant properties. Other non-antioxidant direct effects reported include inhibition of prooxidant enzymes (xanthine oxidase, NAD(P)H oxidase, lipoxygenases), induction of antioxidant enzymes (superoxide dismutase, gluthathione peroxidase, glutathione S-transferase), and inhibition of redox-sensitive transcription factors. 

Lipoxygenases catalyse the regio-specific and stereoselective oxygenation of unsaturated fatty acids. The mammalian enzymes have been detected in human platelets, lung, kidney, testes and white blood cells. The leukotrienes, derived from the enzymatic action of the enzyme on arachidonic acid, have effects on neutrophil migration and aggregation, release of lysosomal enzymes, capillary permeability, induction of pain and smooth muscle contraction (Salmon, 1986). 

Yeadon, M., Eve, D. and Payne, A.N. (1993c). Induction of airway hyperresponsiveness increases the potency of BW B70C, a 5-lipoxygenase inhibitor, to prevent allergic bron-choconstriction in sensitised guinea-pigs. Br. J. Pharmacol. 108, 186P. 

Beierschmitt, W. P, McNeish, J. D., Griffiths, 1C J., Nagahisa, A., Nakane, M. and Amacher, D. E. (2001) Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO) studies in rats and 5-LO knockout mice. Toxicol Sci 63,15-21. 

Kelavkar UP, Cohen C, Kamitani H, Eling TE, Badr KF. Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma correlation with Gleason staging. Carcinogenesis. 21 (2000) 1777-1787. 

Pidgeon GP, Kandouz M, Meram A, Honn KV. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res. 62 (2002) 2721-2727. 

Schuel H, Moss R, Schuel R. 1985. Induction of polyspermic fertilization in sea urchins by the leukotriene antagonist FPL-55712 and the 5-lipoxygenase inhibitor BW755C. Gamete Res 11 41-50, 1985. 

Nassar GM, Morrow JD, Roberts LJ 2nd, Lakkis FG, Badr KF Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J Biol Chem 1994 269 27631-27634. 

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