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Inducible lentiviral vector

Lentiviruses can infect non-dividing cells, thereby allowing stable gene transfer in post-mitotic mature neurons. Lentiviral vector-mediated delivery of short hairpin RNAs (shRNAs) results in persistent knockdown of gene expression. In addition, inducible lentiviral vectors offer a powerful tool for better assessing the function of a gene candidate in targeted neurons by an on-off system [1]. [Pg.332]

Tiscornia, G., Tergaonkar, V., Galimi, F., and Verma, I.M. (2004) Cre recombinase-inducible RNA interference mediated by lentiviral vectors. Proc. Natl. Acad. Sci. USA 101, 7347-7351. [Pg.78]

Cesana D, Sgualdino J, Rudilosso L, Merella S, Naldini L, Montini. Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integration. J Clin Invest. 2012 122 1667-76. [Pg.698]

Azzouz, M., Martin-rendon, E., Barber, R.D., et al. Multicistronic Lentiviral Vector-Mediated Striatal Gene Transfer of Aromatic L -Amino Acid Decarboxylase, Tyrosine Hydroxylase, and GTP Cyclohydrolase I Induces Sustained Transgene Expression, Dopamine Production, and Functional Improvement in a Rat M. J. Neurosci. 22, 10302-10312 (2002)... [Pg.323]

Chang, C. W., Lai, Y. S., Pawlik, K. M. et al. 2009. Polycistronic lentiviral vector for Hit and Run reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 27 1042-9. [Pg.752]

Fig. 7.4 The HIV-1 lentiviral-based vector contains the 5 long terminal repeat (5 -LTR), transactivation response region (TAR), packaging sequence (0), primer binding site (pbs), splice donor (SD) and acceptor (SA) sites, Rev response element (RRE), the 3 long terminal repeat (3 -LTR) and the polypurine tract (ppt) from HIV-1. It contains a cassette with the tat cDNA placed under the LacS-witch II inducible mammalian expression system... Fig. 7.4 The HIV-1 lentiviral-based vector contains the 5 long terminal repeat (5 -LTR), transactivation response region (TAR), packaging sequence (0), primer binding site (pbs), splice donor (SD) and acceptor (SA) sites, Rev response element (RRE), the 3 long terminal repeat (3 -LTR) and the polypurine tract (ppt) from HIV-1. It contains a cassette with the tat cDNA placed under the LacS-witch II inducible mammalian expression system...

See other pages where Inducible lentiviral vector is mentioned: [Pg.306]    [Pg.306]    [Pg.750]    [Pg.245]    [Pg.250]    [Pg.59]    [Pg.143]    [Pg.652]    [Pg.652]    [Pg.713]    [Pg.430]    [Pg.551]    [Pg.1125]    [Pg.404]    [Pg.90]    [Pg.210]    [Pg.316]    [Pg.385]    [Pg.458]    [Pg.69]    [Pg.66]    [Pg.336]    [Pg.341]    [Pg.72]    [Pg.552]    [Pg.125]    [Pg.312]    [Pg.578]    [Pg.439]   
See also in sourсe #XX -- [ Pg.332 ]




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Lentiviral

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