INDEX phenyl derivatives

Names of compounds in the name index include all those shown in the density tables. In addition, phenyl derivative names, other IUPAC systematic names, Chemical Abstracts indexing names and certain trivial or obsolete names are included. 

Lewis, M.L. and Cucurull-Sanchez, L. (2009) Structural pairwise comparisons of HLM stability of phenyl derivatives introduction of the Pfizer metabolism index (PMI) and metabolism-lipophilicity efficiency (MLE). Journal of Computer-Aided Molecular Design, 23 (2), 97-103. 

Lewis ML, Cucurull-Sanchez L. Structural pairwise comparisons of HLM stabdity of phenyl derivatives Introduction of the Pfizer metabohsm index (PMI) and metabohsm-lipophilicity efficiency (MLE). J Comput Aided Mol Des 2009 23 97-103. 

Some diamines carrying very bulky substituents like cardo groups can give colorless polyimides. For example, the bis-9,9-(4-aminophenyl)fluorene (FDA) or brominated and acetylenic FDA derivatives react with 6FDA giving copolymer films62 with low birefringence (low difference between in-plane and out-of-plane refraction index) (Fig. 5.8). A new cardo diamine l,l-bis[4-(4-aminophenoxy)phenyl]cyclododecane (Fig. 5.8) reacts with different aromatic dianhydrides with formation of colorless polyimides.63... 

As 1,2,5-thiadiazole analogues, potent HlV-1 reverse transcriptase inhibitors, some simple 1,2,5-oxadiazoles, compounds 4-6 (Fig. 9), have been synthesized using the traditional Wieland procedure as key for the heterocycle formation [121]. Such as thiadiazole parent compounds, derivative with chlorine atoms on the phenyl ring, i.e., 5, showed the best anti-viral activity. Selectivity index (ratio of cytotoxic concentration to effective concentration) ranked in the order of 5 > 6 > 4. The activity of Fz derivative 6 proved the N-oxide lack of relevance in the studied bioactivity. These products have been claimed in an invention patent [122]. On the other hand, compound 7 (Fig. 9) was evaluated for its nitric oxide (NO)-releasing property (see below) as modulator of the catalytic activity of HlV-1 reverse transcriptase. It was found that NO inhibited dose-dependently the enzyme activity, which is hkely due to oxidation of Cys residues [123]. 

An index of aromatic character based upon statistical evaluation of the deviations in peripheral bond orders has been devised and applied to five-membered ring heterocycles and their mesoionic derivatives including 1,2,3,4-thiatriazole <85TI409> and 5-phenyl-l,2,3,4-thiatriazol-3-oxide <93T8441>. See also <93QSAR146>. 

Several benzyl derivatives exhibit potentially hazardous properties arising from the activation by the adjacent phenyl group, either of the substituent or of a hydrogen atom. Halides, in particular, are prone to autocatalytic Friedel Crafts polymerisation if the aromatic nucleus is not deactivated by electron withdrawing substituents. Individually indexed compounds are ... 

When the excimer lamp of 308 nm is used for the irradiation light source, the refractive index lowers from 1.70 to 1.63. With the mercury-arc lamp the refractive index lowers to 1.58. The larger reduction of the refractive index with the shorter wavelength light derives from the elimination of the side-chain phenyl group. 

Named incorrectly as a 12-aza- -carboline derivative in Ghem. Abstr. 64, 19584 (1966). According to Ghem. Abstr., numbered as a carboline derivative it should be 7-aza-a-carboline. Since Ghem. Abstr. does not index carbolines, but does carbazoles, 1,7-diazacarbazole would be a more appropriate aza name. The correct nomenclature based on the Ring Index system would be 4,8-dimethyl-9-phenyl-9H-pyrrolo[2,3-6 5,4-c ]dipyridine. 

Historically, several names have been used to describe structures of the type indicated as (XI). Originally the derivatives were named for the parent hydrocarbon, fluorene, and were numbered the same as fluorene. Thus, the heteroatom was position 9 and if MR Rg = AsPh [for (XI)], the derivative would be 9-phenyl-9-arsafluorene. Currently, the ring index system is used with the following numbering ... 

The new aniline dye companies in Europe displayed their wares at the 1862 London International Exhibition, where Hofmann, as juror, acquired a number of samples. They included a blue (7) discovered, almost by chance, by two French chemists working near London in 1861. It had first appeared when excess aniline was erroneously added to the aniline red reaction mixture. E. C. Nicholson in 1862 treated the aniline blue with sulfuric acid to yield a more valuable product, the soluble alkali blue, later better known as Cl [Colour Index] Pigment Blue 61. In May 1863, Hofmann found that the aniline blue was a substitution product of aniline red in which three phenyl groups had replaced three hydrogens (Scheme 2). This immediately suggested that other substituted derivatives might be made and perhaps even provide new aniline dyes. Alkylation with ethyl iodide showed that this was indeed correct. Hofmann achieved stepwise replacement of three hydrogens to afford colorants that were, successively, reddish violet, violet blue and then violet, what were soon known as the Hofmann s violets (8). Hofmann next turned to the aniline red process, and found that the colorant was formed not from aniline alone... 

This index is ananged alphabetically, first by the parent carboxylic acid, and then with the positional number of the amino group or functionality. For derivatives, the substituents are listed under the carboxylic acid, amine 4-amino-5-methyl, 3-phenyl-hexanoic acid is, for example, listed as hexanoic acid, 4-amino... 

Utilizing the methodology of selective thiol radical mono-addition to phenyl-acetylene derivatives, Voit and coworkers [236] recently synthesized a series of high refractive index hb polymers (refractive index of 1.68-1.75 with low optical dispersions of 0.004) by using different dithiol and trialkyne monomers. The hb structures produced materials with better performance in terms of light reflection and chromatic dispersion compared with linear analogs that were also synthesized for comparison. 

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