Incyte Genomics

GPCR-PD) from Incyte Genomics. Nucl Acids Res30, 137-141. 

As mentioned in the introduction, there is now a considerable number of molecular biology and related databases available. While some are freely available, such as the DNA sequence collection EMBL [30] and GENBANK [18], others are only freely available to the academic community, such as the protein sequence database SWISS-PROT [15], and others are only available on subscription, such as the EST databases available from the company Incyte Genomics. Academics and pharmaceutical companies also have their own proprietary data which must be integrated into a system so that relationships with publicly available data can be found. 

ESTs are short (200-500bp) DNA sequences generated from the 3 and 5 ends of randomly selected cDNA clones. Quite a large proportion of the sequences in EMBL and GENBANK are actually ESTs. Other propriety data is available from a private company, Incyte Genomics. 

Many biological databases (databanks) are embedded with tutorials that make it easy to explore their facilities. There are three sources of biological databases in-house dedicated sources (private and limited for focused projects), databases assembled by companies (mainly fees for services extensive and high-quality but expensive and restrictive such as Celera Genomics and Incyte Genomics), and public databases (such as GenBank, EMBL and DDBJ). An important distinction exists between primary (archival) and secondary (curated) databases. The primary databases represent experimental results with some interpretation (Table 14.11). Their record is the sequence or structure as it was experimentally derived. 

Functional Genomics Asymetrix CuraGen Dyax Genome Therapies Incyte Millennium Myriad Nova DX Onyx... 

Profile The company was incorporated in 1991 by a founding team of scientists and venture capitalists in 1996, Genome Systems Inc. and Combion Inc. were acquired. Incyte designs, develops, and markets genomic databases and services to pharmaceutical companies on a nonexclusive basis. A wholly owned subsidiary, Genome Systems, Inc., is located in St. Louis, Missouri. The combined companies employ more than 500 people. 

DNA chips aie provided by more than 20 companies (e.g., Affymetrix, A Gene, Amersham Pharmacia Biotech, Genometrix, Genomic Solutions, Hyseq Incyte Pharmaceuticals, Nanogen, etc.), protein chips by one company (Ciphergen) and microfluidic chips by several companies [Aclara Biosciences, Caliper (Cellomics), Cepheid and Orchid Biocomputer]. 

Rockville, MD) Incyte (Palo Alto, CA) Biotech Co. 3 1994-1998 Genomics ... 

Diagnostic and pharmacogenomic kits based on leads from Incyte s, SmithKlein Beecham s, and Human Genome Science s (Rockville, MD) databases... 

Incyte Microarray Systems Genomics 6519 Dumbarton Dr., Fremont, CA 94555-3619, USA... 

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