Increased pulmonary residual volume

In lung function tests, high-dose aerosolized pentamidine (600 mg/month) was associated with an increased pulmonary residual volume, reduced flow rates, and increased airway reactivity (SEDA-18, 291). 

Pulmonary function tests (PFTs) indicate decreased forced expiratory volume in 1 second (FEN/,), decreased forced vital capacity (FVC), and increased residual volume. Values are typically worse during acute pulmonary exacerbations. 

Schwartz et al. (1990) followed 20 accidentally exposed individuals for 12 yr and reported an increasing prevalence of low residual volume over time and an increase in airway reactivity. These findings suggest that acute exposure has longterm pulmonary sequella and that the presence of air trapping indicates long-term injury. Unfortunately, the chlorine exposure was not quantified. 

C asthmatic (5 men and S wmen, aged 18-25) 0 0,0.8, or 1.8 45 min (15 min exercise, 15 min nest, 15 min exercise) No treatment related effects, including increase in severity of upper respiratory lower respiratory, other symptoms no significant differences between treated and control groups in pulmonary function tests (total respiratory resistance, thoracic gas volume at functional residual capacity, forced expiratory volume, forced viral capacity, maximal flow at 50% and 75% of expired vital capacity) no changes in nasal power data between treated and control groups Stevens et al. 1992... 

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