Inclusion body myositis, sporadic muscle fibers

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Pathogenesis of sporadic inclusion-body myositis role of aging and muscle-fiber degeneration, and accumulation of the same proteins as in Alzheimer and Parkinson brains... 

Vattemi G, Nogalska A, King Engel W et al. (2009) Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis. Acta Neuropathol 117, 569-574. 

Askanas V, Engel WK, Yang CC etal. (1998) Light and electron microscopic immunolocaUzation of preseni-lin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive indusion-body myopathy. Am J Pathol 152, 889-895. 

Askanas V, Sarkozi E, Alvarez RB et al. (1996) Superoxide dismutase-1 gene and protein in vacuolated muscle fibers of sporadic inclusion-body myositis, hereditary inclusion-body myopathy, and cultured human muscle after beta-amyloid precursor protein gene transfer. Neurology 46, A487. 

Nogalska A, Engel W, Askanas V. (2007) Abnormalities of peroxisome proliferator-activated receptor gamma in sporadic inclusion-body myositis muscle fibers. Ann Neurol 62, S13. 

Guerin C, SinnreichM, Karpati G. (2008) Transcri-tional dysregulation in muscle fibers in sporadic inclusion body myositis (slBM). Neurology 7 (Suppl. 3), A304. 

Nogalska A, D Agostino C, Engel WK et al. (2010) Novel demonstration of amyloid-beta oligomers in sporadic inclusion-body myositis muscle fibers. Acta Neuropathol 120, 661-666. 

Wojcik S, Paciello O, Engel WK et al. (2007) In sporadic inclusion-body myositis muscle fiber cytoplasm, cytochrome c aggregates with a-synudein and amyloid-beta precursor protein, but does not activate caspase-3. Neuromuscul Disord 17, 853. 

Nogalska A, Terracciano C, D Agostino C et al. (2009) p62/SQSTMl is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol 118, 407- 13. 

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