Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

In Vivo Dermal Microdialysis

Originating from the neurosciences, the microdialysis technique has been used since several years to monitor drug absorption and disposition or the levels of endogenous substances in the extracellular space of different organs and fluids, such as bone, lung, liver, brain, and blood. The method has evolved from its use in different animal species to the human microdialysis during the late 80s [35], [Pg.10]

The technique consists of a microdialysis probe, a thin hollow tube made of a semi-permeable membrane usually around 200-500 /xm in diameter, which is implanted into the skin and perfused with a receiver solution that recovers the unbound permeant from the local area. In principle, the driving force of dialysis is the concentration gradient existing between two compartments separated by a semi-permeable membrane. For skin under in vivo conditions, these compartments represent the dermal or subcutaneous extracellular fluid (depending on the probe position) and an artificial physiological solution inside the probe [36-38], [Pg.10]

The relative recovery (RR) of the probe, essential for data interpretation, is calculated using the retrodialysis method, which assumes that the net transport through the microdialysis membrane from the perfusate to the surrounding tissues equals the net transport from the tissues into the perfusate. The equation for calculation is represented as follows [39]  [Pg.11]


See other pages where In Vivo Dermal Microdialysis is mentioned: [Pg.10]   


SEARCH



Dermal

In vivo microdialysis

Microdialysis

© 2024 chempedia.info