In Vitro Tests Undergoing Validation by ICCVAM

ICCVAM has evaluated alternative test methods for acute oral toxicity, genetic toxicity, biologies, immunotoxicity, dermal corrosion and irritation, ocular toxicity, developmental toxicity, pyrogeni-city, and endocrine disrupter effects (ICCVAM 2007). As examples, alternative test systems for dermal corrosion and irritation are described in the following text. [Pg.60]

ICCVAM has validated three tests for dermal corrosion, including Corrositex , EPISKIN / EpiDerm, and Transcutaneous Electrical Resistance (TER). [Pg.60]

Corrositex uses a synthetic membrane-based detection system to determine the UN packing group classification of chemicals, consumer products, or other hazardous materials. [Pg.60]

EPISKIN is a three-dimensional human skin model composed of a human collagen (Types El and I) matrix, representing the dermis, covered with a film of Type IV human collagen and stratified differentiated epidermis derived from human keratinocytes. [Pg.60]

The EpiDerm (EPI-200) skin model is mechanistically and functionally related to EPISKIN. The assay consists of normal human epidermal keratinocytes, which have been cultured in a chemically defined medium to produce a stratified, highly diEerentiated, organotypic tissue model of the human epidermis. [Pg.60]

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