Implications for future research

In the REMARK system, estimated effects (e.g., hazard ratios) with confidence intervals for the marker were recommended for univariant and key multivariable analyses, and a Kaplan-Meier plot was recommended to represent the effect of a tumor marker in a time-to-event outcome. The discussion section should interpret the results in the context of the pre-specified hypothesis and describe limitations of the study as well as implications for future research and clinical value. These guidelines were advocated for reporting of tumor marker studies in breast cancer research and treatment (63). 

Parasuraman A, Zeithaml VA, Berry LL. 1985. A conceptual model of service quality and its implications for future research. J Market 49 41. 

The European Union Directive on Good Clinical Practice in Clinical Trials Implications for Future Research... 

Wengel SP, Reccaforte WH, Burke WJ. Donepezil improves symptoms of delirium in dementia implication for future research. J Geriatr Psychiatry Neurol 1998 11 159-161. 

Burtscher, M. J., Manser, T. (2012). Team mental models and their potential to iminove teamwork and safety A review and implications for future research in healthcare. Safety Science, 50, 1344-1354. 

Parasuraman, A., V.A. Zeithaml, L.L. Berry. 1985. A Conceptual Model of Service Quality and Its Implications for Future Research. Journal of Marketing 49(4), 41-50. 

Trog D, Bank P, Wendt TG et al. (1999) Daily amifostine given concomitantly to chemoradiation in head and neck cancer. A pilot study. Strahlenther Onkol 175 444-449 Tsoutsou PG, Koukourakis MI (2006) Radiation pneumonitis and fibrosis mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys 66 1281-1293... 

Burke, L.A. and Hutchins, H.M. (2001). Training transfer an integrative literature review and implications for future research. Human Resource Development Review, 6(3), 263—296. 

Tannock, G.W. (2005) New perceptions of the gut microbiota implications for future research. Gastroenterol Clin NorthAmM, 361-382. 

These findings provided a strong incentive for the initiation of intervention studies to investigate whether a lack of dietary antioxidants is causally related to chronic disease risk and if providing antioxidant supplements confers benefits for the prevention and treatment of these conditions. This article summarizes the findings of the largest primary and secondary trials published to date and considers their implications for future research and current dietary advice. 

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