Immunoglobulin gene organization

Pascual, V., Capra, J.D. (1991). Human immunoglobulin heavy-chain variable region genes, organization, polymorphism, and expression. Adv. Immunol., 49, 1-74. 

Adams, J.M. (1980). The organization and expression of immunoglobulin genes. Immunology Today 1, 10-17. 

Blomberg, B., Traunecker, A., Eisen, H., Tonegawa, S. (1981). Organization of four mouse X light chain immunoglobulin genes. Proc. Natl. Acad. Sci. USA 78,3765-3769. 

Tonegawa, S., Brack, C., Hozumi, N., Pirrotta, V. (1977a). Organization of immunoglobulin genes. Cold Spring Harb. Symp. Quant. Biol. 42,921-931. 

Fig. 3. Organization of murine and human immunoglobulin loci. Each panel shows the murine (M.) and human (H.) immunoglobulin locus organization. Much of this figure is speculative. See text for details and references. Details of CM gene organization are reviewed by Honjo [5] and elsewhere in this volume.

Reviews dealing with the structure of immunoglobulins, the organization of immunoglobulin genes, the antibody-combining site, and the structural basis of antibody complementarity have been published. 

Kodaira, M., Kinashi, T., Umemura, I., et al. (1986). Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J. Mol. Biol., 190,529-541. 

Walter, M.A., Surti, U., Hofker, M.H., et al. (1990). The physical organization of the human immunoglobulin heavy chain gene complex. EMBO J, 9, 3303-3313. 

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