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Imine salts Imines

There is an experimental variation in which an W-phenacylpyridinium salt is heated with an aniline[4]. This reaction can also be readily accommodated to the mechanism involving an imine intermediate. There are a few examples of use of other types of a-halokctoncs[5,6] but most of the synthetic applications have been to 2-arylindoles. [Pg.78]

Besides being useful precursors to pyrroles pyridine-2-ones -4-ones, -4-thiones. and -4-imines 4-alkylidene-dihydropyridines thiophenes 1,2,4-triazoles thiapyrane-2-thiones, isoquinoline-3-ones isoben-zothiophenes and 4-mercaptoimidazolium hydroxide inner salts, mesoionic thiazoles are potentially useful in the construction of molecules with herbicidic (39). central nerve stimulating, and antiinflammatory properties (40,41). Application in dye synthesis has likewise been reported (42). [Pg.15]

Polyamines can also be made by reaction of ethylene dichloride with amines (18). Products of this type are sometimes formed as by-products in the manufacture of amines. A third type of polyamine is polyethyleneimine [9002-98-6] which can be made by several routes the most frequently used method is the polymeriza tion of azitidine [151 -56 ] (18,26). The process can be adjusted to vary the amount of branching (see Imines, cyclic). Polyamines are considerably lower in molecular weight compared to acrylamide polymers, and therefore their solution viscosities are much lower. They are sold commercially as viscous solutions containing 1—20% polymer, and also any by-product salts from the polymerization reaction. The charge on polyamines depends on the pH of the medium. They can be quaternized to make their charge independent of pH (18). [Pg.33]

The most generally useful method for acylation or formyl a ti on of pyrroles is the Vil smeier-Ha ack reaction (32,33). The pyrrole is treated with the phosphoryl complex of A/ A -dialkjlamide and the intermediate imine salt is hydroly2ed. [Pg.357]

The most useful general method for the C-acylation of pyrroles is the Vilsmeier-Haack procedure in which pyrrole is treated with the phosphoryl chloride complex (55a, b) of an AiA-dialkylamide (54). The intermediate imine salt (56) is hydrolyzed subsequently under mildly alkaline conditions to give the acylated pyrrole (57). On treatment of the imminium salt (56 R =H) with hydroxylamine hydrochloride and one equivalent of pyridine and heating in DMF, 2-cyanopyrrole (58) is formed (80CJC409). [Pg.51]

In addition to (461), Dorn has described the imine (463) isolated from 5-amino-l-methylpyrazole and arenesulfonyl chloride (80CHE1). Upon heating, or in the presence of triethylamine, it undergoes rearrangement to the more stable 5-bis(arylsul-fonamido)pyrazoles (464). 5-Iminopyrazolines (461) react with acyl chlorides at the exocyclic nitrogen atom to afford amidopyrazolium salts (B-76MI40402). [Pg.262]

Water-soluble polymers and polyelectrolytes (e.g., polyethylene glycol, polyethylene imine polyacrylic acid) have been used success-hilly in protein precipitations, and there has been some success in affinity precipitations wherein appropriate ligands attached to polymers can couple with the target proteins to enhance their aggregation. Protein precipitation can also be achieved using pH adjustment, since proteins generally exhibit their lowest solubility at their isoelectric point. Temperature variations at constant salt concentration allow for frac tional precipitation of proteins. [Pg.2060]

Ethylene imine Hydrazine hydrate Hydrogen sulfide. Hydroxylamme salts Inorganic Hg. compounds lodates Iodides... [Pg.1028]

The formation of 88 is postulated to be occurring by the nucleophilic attack of a hydride ion (47), abstracted from the secondary amine, on the a-carbon atom of the iminium salt (89). The resulting carbonium ion (90) then loses a proton to give the imine (91), which could not be separated because of its instability (4H). In the case of 2-methyIhexamethylenimine, however, the corresponding dehydro compound /l -2-methylazacyclo-heptene (92) was isolated. The hydride addition to the iminium ion occurs from the less hindered exo side. [Pg.28]

The alkylation of imines by an alkyl halide to give an iminium salt will be illustrated by selected reactions over a period of years. A more complete survey is available (88). Decker and Becker (89) prepared a number of iminium salts (91, for example) by mixing methyl iodide and aromatic imines in benzene. 2,5-Dimethyl-2-pyrroline (92) has been alkylated and the... [Pg.79]

Experimental evidence, obtained in protonation (3,6), acylation (1,4), and alkylation (1,4,7-9) reactions, always indicates a concurrence between electrophilic attack on the nitrogen atom and the -carbon atom in the enamine. Concerning the nucleophilic reactivity of the j3-carbon atom in enamines, Opitz and Griesinger (10) observed, in a study of salt formation, the following series of reactivities of the amine and carbonyl components pyrrolidine and hexamethylene imine s> piperidine > morpholine > cthyl-butylamine cyclopentanone s> cycloheptanone cyclooctanone > cyclohexanone monosubstituted acetaldehyde > disubstituted acetaldehyde. [Pg.102]

When the 1-monoximes or dioximes of 4-acetyl-l-tetralones are hydrogenated in the presence of palladium, mixtures of diastereoisomeric 1-aminotetralones are formed. The m-aminoketone isomers readily form dehydrobenzoisoquinuclideines (3,4-disubstituted-1,4-dihydro-1,4-ethano-isoquinolines). Quaternary immonium salts prepared from these bicyclic imines are then converted by bases to bicyclic enamines [2,4-disubstituted-3-alkylidene-1,4-ethano-1,2,3,4-tetrahydroisoquinolines (25)]. [Pg.256]

With imines, salts formation is accompanied by characteristic spectral changes (153) (a) a bathochromic shift in the ultraviolet region by as much as 50 m/i, according to compound type and to properties of any auxochrome present, and (b) a high frequency shift of the... [Pg.275]

Stretching vibration in the infrared region. The imine salts possess an active hydrogen, whereas their quaternization products exhibit the same spectral properties as the enamine salts (187). [Pg.275]

Spelling of amonium, imonium, and iminium indicates derivation from amine and imine onium salts. [Pg.314]

Anastassiou has summarized in two reviews the knowledge about IH-azonine (41a) [72ACR281 78AHC(23)55]. Compound 41a as well as its salts (N M" ) are aromatic compounds which exist as such and not as imine polyenic forms. Tliis compound demonstrates a valence isomerism 41a/41b similar to that of l//-azepine (14a/14c see Section II,A,1) the transformation 41a 41b occurs upon irradiation. 9-Azabicyclo[6.1.0]nona-2,4,6-triene 41b displays no tendency to thermal isomerization to 41a at ambient temperature (72ACR281). [Pg.10]

Tile chloro derivative 33a (not isolated) interacts with pyridine-2,3-diamine in dichloromethane at room temperature to yield 73 (85%) (93BSB357). A further example deals with the reaction between the salt 39 and benzene-1,2-diamine, which gives an imine 74 (80%) under special experimental conditions (93BSB357). In order for the reaction to work, the salt 39 must be isolated prior to its employment (Section IV,C,8). No traces of the diimines were detected for both cases. However, the experimental conditions were not optimized for this purpose since no more than three equivalents of the diamines were used (Scheme 23). [Pg.208]


See other pages where Imine salts Imines is mentioned: [Pg.259]    [Pg.851]    [Pg.105]    [Pg.735]    [Pg.362]    [Pg.456]    [Pg.69]    [Pg.174]    [Pg.263]    [Pg.270]    [Pg.510]    [Pg.539]    [Pg.551]    [Pg.567]    [Pg.680]    [Pg.2057]    [Pg.5]    [Pg.67]    [Pg.80]    [Pg.256]    [Pg.184]    [Pg.205]    [Pg.205]    [Pg.213]    [Pg.79]   


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Addition to imines, iminium salts and related compounds

Imine salts

Imine salts

Imine salts from Grignard reagents

Imine salts from aldehydes

Imine salts from alkynes

Imine salts from amides

Imine salts from amines

Imine salts from ammonia

Imine salts from azides

Imine salts from carboxylic acids

Imine salts from enamines

Imine salts from isocyanates

Imine salts from ketones

Imine salts from metalated imines

Imine salts from nitriles

Imine salts from oximes

Imine salts hydrolysis

Imines 2-azetidiniminium salts from

Imines and Iminium Salts

Imines lithium salts

Imines, Iminium Salts, and Related Compounds

Imines, acetylation salts

Of imine salts

Quaternary imine salts, hydrolysis

Salts and Neutral Imines

Sydnone imine salts

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