Imaging mass spectrometry protein mapping, tissue section

Alternatively, imaging mass spectrometry (IMS) using matrix-assisted laser des-orption/ionization (MALDI) can be used to simultaneously map the distribution of pharmaceuticals in thin tissue sections to determine how a drug is distributed in animal tissues [6-9], MALDI-IMS has been extensively employed to measure macromolecules such as peptides and proteins in tissue sections [10-13] (Figure 11.1). Although MALDI-IMS has been applied almost exclusively as an analytical tool for... 

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