IGF system

There is only one major system of interacting growth factors and receptors in the fetus — the insulin (INS) and insulin-like growth factor (IGF) system (Table 1 and Fig. 1). Ignoring various binding proteins that modulate IGF actions in tissues and... 

Blakesley VA, Butler AA, Koval AP, Okubo Y, LeRoith D 1999 IGF-I receptor function transducing the IGF-I signal into intracellular events. In RG Rosenfeld, CT Roberts (eds) The IGF system Molecular biology, physiology and clinical applications. Humana Press, New Jersey, p 143-163... 

McMahon I have a more general question about how the IGF system works. Your explanation for the absence of a tissue-specific effect of modulating IGF levels presupposes that there would be some data that suggest that IGF2 is acting locally. It is certainly expressed broadly throughout the whole embryo. An alternative hypothesis is that there are key places where it has been expressed during embryonic fetal development that are important and some places that are unimportant. What has been done in terms of tissue-specific removal or activation of this pathway ... 

Voskuil, DW, A Vrieling, CM Korse et al. 2008. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer surviviors and women at high familial breast cancer risk. Nutr Cancer 60(3) 342-353. 

The IGF system involves complex regulatory networks that operate at the whole organism, cellular and subcellular levels. Key molecules involved are the... 

K6. Kimura, G., Kasuya, J., Giannini, S., Honda, Y., Mohan, S., et al., Insulin-like growth factor (IGF) system components in human prostatic cancer cell-lines LNCaP, DU-145, and PC-3 cells. Int. J. Urol. 3, 39-46 (1996). 

The growth hormone/insulin-like growth factor (IGF) axis plays a role in ovarian responsiveness. The IGF system comprises of IGF-I and -II and their binding-proteins, IGF-binding proteins (BP)-l to -6 (G3). 

Nabeyrat E, Besnard V, Corroyer S et al (1998) Retinoic acid-induced proliferation of lung alveolar epithelial cells relation with the IGF system. Am J Physiol 275(1 Pt 1) L71-L79... 

Normal proliferation of somatic cells requires both thyroid hormone and growth hormone. Thyroid hormone stimulates growth hormone secretion, and many thyroid hormone actions on the insulin-Uke growth factor (IGF) system can be explained by this mechanism. 

Lang, C. H., Fan, J., Cooney, R., and Vary, T. C. IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis. Am J Physiol 270 (1996) E430 37. 

Samani, A. A., Yakar, S., Leroith, D., and Brodt, P. 2007. The role of the IGF system in cancer growth and metastasis Overview and recent insights. Endocrine Reviews, 28,20. 

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