Identification control-relevant

W. Luo, M.N. Karim, A.J. Morris and E.B. Martin, Control relevant identification of a pH waste water neutralisation process using adaptive radial basis function networks. Computers Chem. Eng., 20(1996)S1017... 

Control-Relevant Identification / 16.1.2 Frequency Content of the Innul Sionnl / 16 11 Model Order... 

This Chapter provides information on available certified reference and quahty control materials relevant for use in the measurement of airborne contaminants in occupational hygiene. The majority of measurements made in this area worldwide are solvents, dust (total, respirable), elements, oil mist, quartz, fiber identification (asbestos, man-made fibers), mists and gases. 

For nonpharmacopeial materials a full specification should be included in the application. This should include appropriate tests and requirements for physical characteristics, identification, relevant purity tests, and performance-related tests. Characteristics likely to influence bioavailability of the finished product should be controlled. Routine tests and specifications should be described. Methods should be validated. The material should be fully characterized, with full data on the chemistry concerned and including consideration of the safety of the excipient. Any relevant European Directive requirements or other international specifications should be met, but additional requirements might apply depending on the intended use of the product—e.g., for materials to be used in sterile products. 

Documentation comprises procedures, instructions, test methods,batch records, and so on that are documented and controlled. Documentation is prepared, reviewed, and approved by qualified personnel. Approved copies of documents are distributed to relevant departments and superseded copies are retrieved and archived. The retention period for each type of document is specified. Documents are issued with document and version numbers for ease of identification and reference. Master copies of documents are filed at secured locations with authorized access. Master copies stored in electronic media require validation in accordance with FDA regulation 21 CFR Part 11 (see Section 9.6.3) to assess the security of access and data integrity. Operators are trained and retrained to only apply the latest approved documents. 

The most important step in a structure-property correlation is to discover the set of relevant structural parameters that control the property, as well as any related and readily available property parameters. The identification of these parameters may be suggested by theoretical understanding or by empirical observations of experimental measurements. There are some generally useful methods to discover the independent variables [x,] for a specific property in a set of molecules, such as the boiling points of the normal paraffins. 

The USEPA established a National Remedy Review Board in 1995 to review all remedies. This board has saved an estimated 31 million, and future cost reductions of more than 725 million are expected (USEPA, 1998b). The remedial investigation (RI) will also include identification of "applicable or relevant and appropriate requirements" (ARARs). These are remediation standards, standards of control, or other criteria or limitations developed by federal or state law. Applicable requirements are those that have been previously used at a CERCLA site for the same waste. Relevant and appropriate requirements are those not formerly used for waste at a CERCLA site but which address the problem. Advisories and guidance to be considered can also be issued, but they are not as binding. 

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