Twin drugs identical

I. INDRODUCTION B. Hybrids as enzymes B. Identical twin drugs... 

The association of two identical pharmacophoric entities will generate an identical twin drug which is equivalent to a homodimer derivative. A compound, where two different pharmacological entities are bounded, is called a non-identical twin drug or heterodimer. The first design strategy is equivalent to a duplication/dimerization process of an active compound or lead. The aim of this approach is the production of a more potent and/or more selective drug... 

IV. Binding Mode Analysis of Identical and Non-Identical Twin Drugs... 

IV. BINDING MODE ANALYSIS OF IDENTICAL AND NON-IDENTICAL TWIN DRUGS... 

A. Identical and non-identical twin drugs interacting with two adjacent binding sites located on the same macromolecule... 

FIGURE 18.45 Molecular Structure of identical twin drugs for GPCR homodimers. 

Contreras, J. M., Bourguignon, J. J. Identical and non-identical twin drugs. In The Practice of Medicinal Chemistry (Wermuth, C. G., Ed.). Academic Press London, 2003, pp. 251-273. 

D Twin drugs acting as DNA ligands E Other identical twin drugs of 259... 

Identical and non-identical twin drugs may be combined by a linker, a no linker or in overlap mode (Fig. 16.2). The spacer group can be a single bond, a polymeric chain... 

Two examples of twin drugs are given in Fig. 16.3. Duplication of aspirin led to the identical twin drug diaspirin where the connection mode is a no linker mode. Association of salicyclic acid and paracetamol with an overlap mode gave the non-identical twin drug acetaminosalol. 

Identical twin drugs have shown increasing potencies and/or modified selectivity profiles as receptor ligands, when compared with their corresponding single drug. 

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