Twin drugs non-identical

The association of two identical pharmacophoric entities will generate an identical twin drug which is equivalent to a homodimer derivative. A compound, where two different pharmacological entities are bounded, is called a non-identical twin drug or heterodimer. The first design strategy is equivalent to a duplication/dimerization process of an active compound or lead. The aim of this approach is the production of a more potent and/or more selective drug... 

IV. Binding Mode Analysis of Identical and Non-Identical Twin Drugs... 

IV. BINDING MODE ANALYSIS OF IDENTICAL AND NON-IDENTICAL TWIN DRUGS... 

A. Identical and non-identical twin drugs interacting with two adjacent binding sites located on the same macromolecule... 

Contreras, J. M., Bourguignon, J. J. Identical and non-identical twin drugs. In The Practice of Medicinal Chemistry (Wermuth, C. G., Ed.). Academic Press London, 2003, pp. 251-273. 

Identical and non-identical twin drugs may be combined by a linker, a no linker or in overlap mode (Fig. 16.2). The spacer group can be a single bond, a polymeric chain... 

Two examples of twin drugs are given in Fig. 16.3. Duplication of aspirin led to the identical twin drug diaspirin where the connection mode is a no linker mode. Association of salicyclic acid and paracetamol with an overlap mode gave the non-identical twin drug acetaminosalol. 

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