Synthesis Ideals

Wender, P. Miller, B.L. (1993) Toward the Ideal Synthesis Connectivity Analysis and Multibond-Forming Processes. In Organic Synthesis Theory and Applications, Vol. 2 (ed. T. Hudlicky), pp. 27-65. JAl Press, Greenwich, CT. 

The ideal synthesis creates a complex skeleton... in a sequence only of successive construction reactions involving no intermediary refunctionalizations, and leading directly to the structure of the target, not only its skeleton but also its correctly placed functionality. Hendrickson JB (1975) J Am Chem Soc 97 5784... 

There is no rigid definition of what constitutes a suitable synthesis. The major criterion by which syntheses are judged is the potential value to the scientific community. An ideal synthesis is one which presents a new or revised experimental procedure applicable to a variety of related compounds, at least one of which is critically important in current research. However, syntheses of individual compounds that are of interest or importance are also acceptable. 

Wender PA, Handy ST, Wright DL (1997) Towards the ideal synthesis. Chem Ind 765-768 14. Zhu JP (2003) Recent developments in the isonitrile-based multicomponent synthesis of heterocycles. Eur J Org Chem 1133-1144... 

Obviously, equation 8 suggests that the ideal synthesis gas reactor should operate at a CH4 02 mole ratio of 2 1 (29.6% CH4 in air) if total conversion of the reactants occurs. At high enough temperatures, this mixture is completely converted to H2 and CO at thermodynamic equilibrium. Below about 1270 K, the equilibrium mole fraction of carbon becomes significant. Hence, a reactor must be maintained above 1270 K to avoid carbon formation. 

In order to properly consider the trade-offs between capital, energy, and resilience at the stage of matches, investigate the optimum choice of ATm. Actually, in an ideal synthesis algorithm, these trade-offs should be evaluated directly and not by means of a possibly artificially chosen value of ATm. 

Overall MCRs are a big step towards the ideal synthesis, which, according to Wender et al. can be measured by parameters such as the step count, overall yield, selectivity, cost, scale, resource requirements, waste stream, development time, execution time and personnel [8], The discovery of novel IMCRs are explained and several conceptually different approaches towards this goal, with an emphasis on our recent contributions in this area are shown. 

The 27A1 spectrum shows a sharp line at 41.2 ppm, a broad signal around 7 ppm and additional signals from -11 till -24 ppm. We have experienced that the broad line around 6 ppm arises from non-ideal synthesis conditions, when an excess of amorphous A1 is present in the sample. Chemical analysis (Table IV) confirms that there is an excess of A1 in the product, when the A1 T-atom fraction exceeds 50%. Apart from the 7 ppm signal, the 27A1... 

Wender PA, Handy ST, Wright DL (1997) Towards the ideal synthesis. Chem Ind 765 767-769... 

E S S CONTENTS Preface, Tomas Hudlicky. Modern Synthetic Design Symmetry, Simplicity, Efficiency and Art, Tomas Hudlicky and Michael Natchus. Toward the Ideal Synthesis Connectivity Analysis, Paul Wender and Benjamin L. Miller. Application of Graph Theory to Synthesis Planning Complexity, Reflexivity and Vulnerability, Steven H. Bertz and Toby J. Sommer. Asymmetric Reactions Promoted by Titanium Reagents, Koichi Narasaka and Nobuharu Iwasawa. The Use of Arene Cis-diols in Synthesis, Stephen M. Brown... 

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