Connectivity Analysis

FIGURE 6.11 Radial pentagon for classical resolution of 1-naphthen-l-ylethylamine [9], Note that the yield of the diastereomeric salt in the first step is less than 50%. 

Here we introduce a structure parsing algorithm (SPA) for graphical factorization according to the following steps  

For the first generation graph, Gl, assign next nearest neighbor vertices (atoms) as plus or minus as appropriate from GO. 

Continue along chains and rings in this way to come up with G2, G3, etc., graphs. 

Look for stretches or loops with continuously alternating plus and minus signs. The more plus-minus alternations there are, the easier it is to synthesize the molecule. 

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Wender, P. Miller, B.L. (1993) Toward the Ideal Synthesis Connectivity Analysis and Multibond-Forming Processes. In Organic Synthesis Theory and Applications, Vol. 2 (ed. T. Hudlicky), pp. 27-65. JAl Press, Greenwich, CT. 

Analysis of the data on temperature measured in boreholes made an important contribution ito ideas about SAT changes in the past. For instance, Bodri and Cermak (1999) noted that if the amplitude of long-term SAT variations during transitions from glaciations to interglacial periods had reached 10K-15K in the Holocene (the last 10,000-14,000 years), changes of several °K would have taken place on time scales from decades to centuries. In this connection, analysis has been made of the data on the vertical profiles of temperature measured at different depths in boreholes, and maps have been drawn of SAT changes over the Czech Republic, which took place between 1100 bc to 1300 bc (small climatic optimum), between 1400 and 1500, and between 1600 and 1700 (main phases of the Little Ice Age). 

Cipollini PB, Pandya DN. 1989. Connectional analysis of the ipsilateral and contralateral afferent neurons of the superior temporal region in the Rhesus monkey. J Comp Neurol 281 567-585. 

Correlation of percolation connectivity analysis parameters with structural heterogeneity... 

Glennon, R.A., Kier, L.B. and Shulgin, A.T. (1979). Molecular Connectivity Analysis of Hallucinogenic Mescaline Analogs. J.Pharm.ScL, 68,906. 

E S S CONTENTS Preface, Tomas Hudlicky. Modern Synthetic Design Symmetry, Simplicity, Efficiency and Art, Tomas Hudlicky and Michael Natchus. Toward the Ideal Synthesis Connectivity Analysis, Paul Wender and Benjamin L. Miller. Application of Graph Theory to Synthesis Planning Complexity, Reflexivity and Vulnerability, Steven H. Bertz and Toby J. Sommer. Asymmetric Reactions Promoted by Titanium Reagents, Koichi Narasaka and Nobuharu Iwasawa. The Use of Arene Cis-diols in Synthesis, Stephen M. Brown... 

Glennon, R. A., L. B. Kier, and A. T. Shulgin. 1979. Molecular connectivity analysis of hallucinogenic mescaline analogs. J. Pharm. 

Chapter 6 discusses the question of optimization, radial pentagon analysis to assess individual reaction greenness, connectivity analysis as a complementary tool to letrosynlhesis in the design of synthesis plans, and probability analysis to assess the likelihood that a given reaction can be called green. ... 

Appropriate application of connectivity analysis especially for ring constructions can go a long way in coming up with direct synthetic routes to such targets as was done in the cyclohexanone example given in Section 9.1.3. 

There are two paradigms for measuring system performance connectivity analysis and serviceability analysis. Connectivity analysis determines whether two points in the system remain connected and so can be used to determine whether a demand node (customer) remains connected to a source node. Serviceability analysis determines not just whether a customer is connected to a service but also what the quality of that service is. 

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