Ic-Carrageenan

Process development with Brevibacterium ammoniagenes (introduced in 1974), similarly to the development in the i-aspartate process led to 25-fold improvements, mainly through use of a Brevibacteriumflavum strain immobilized on ic-carrageenan gel with polyethyleneimine (PEI) crosslinker, so that a half life of 310 days at 37°C has been achieved. 

This approach was satisfactorily applied to other biopolymer gelled systems, including agarose (Watase and Nishinari, 1987a), HM pectin/dimethyl sulfoxide (DMSO) gels (Watase and Nishinari, 1993), ic-carrageenan (Watase and Nishinari, 1987b) and LM pectin/Ca + and LM pectin/Ca /sucrose systems (Fu and Rao, 1999). 

Stading, M. and Hermansson, A. M. 1993. Rheological behaviour of mixed gels of ic-carrageenan-locust bean gum. Carbohydr. Polym. 22 49-56. 

Fig. 8 Concentration dependence of Dapp for K4[Ru(CN)5] in the solids of agarose (2wt%), ic-carrageenan (2wt%), and aqueous solution containing 0.1 M KNO3 (reprinted with permission from Elsevier [49])...

To expand our understanding of the anti-inflammatory activity of the well-known oleanolic acid isolated from one of its best characterised sources, the seeds of Luffa cylindrica (Cucurbitaceae), a series of experiments were performed to correlate complement activity with the inflammation caused by both carrageenan and Freund s adjuvant, in presence and absence of oleanolic acid and ibuprofen, which were administered at 60 mg/kg i.p. It was concluded that the effect of this triterpenoid must be mediated by its anti-complementary activity 73]. An analogous conclusion was drawn regarding the activity of boswel ic acids in the same tests [74]. 

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