I Cytotoxics

The mechanism of Ag(I) cytotoxicity is unknown. Cell wall damage may be important and it has been shown that Cys-150 in the enzyme phosphomannose isomerase, an essential enzyme for the biosynthesis of Candida albicans cell walls, is the Ag(I) target in this organism (330). Silver resistant bacteria are known, but only recently has significant progress been made in understanding the resistance mechanisms (637). 

Complement components—Clr, Cl and C2 Complement factors—B, D and I Cytotoxic cell proteases—granzymes A to H Mast cell proteases—... 

Chemical constituents of Podocarpaceae. I. Cytotoxic constituents from Podocarpus nagi. Xu, Y. Fang, S. HuaxueXuebao 1989,47,1080-1086. 

METHOTREXATE FLUOROURACIL i cytotoxic effect of methotrexate when fluorouracil is administered prior to methotrexate Fluorouracil prevents the conversion of reduced folates to dihydrofolate Always administer methotrexate prior to fluorouracil... 

Jacobson S, Shida H, McFarlin DE, Fauci AS, Koenig S (1990) Circulating CD8-I- cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 348 245-248. 

Table I. Cytotoxic activity of 3-alkylpyridine and 3-alkylpyridinium compounds from marine sponges on...

Dai, Y, Cederbaum, A. I. Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells. J. Pharmacol. Exp. Then 1955,273, 1497-1505. 

P.itgfpgngsi Spongiadiol (257), Epispon-giadiol (258), Isospongiadiol (259) Sponge, Sp[Pg.534]

Sovadinova, L Blaha, L. Janosek, J. Hilscherova, K. Giesy, J. R Jones, P. D. Holoubek, I. Cytotoxicity and aryl hydrocarbon receptor-mediated activity of N-heterocyclic polycyclic aromatic hydrocarbons structure-activity relationships. Environ. Toxicol. Chem. 2006, 25, 1291-1297. 

Major Applications Microelectronics,5 power transmission fluid, insulators for electronicdevices, photoresists,8 display device, imaging process,semiconductors, diesel fuel additives, 12 battery,i3 adhesive,w paints,is inks,i chalk,ii leather,is textiles,is dye synthesis,i5soil products Safety/Toxicity Carcinogenicity i. cytotoxicity, 3 genotoxicity,23 mutagenicity,24 tumorigenicity s... 

Safety/Toxicity Antimalarial drug toxicity, 1 cardiotoxicity.i cytotoxicity, hepatotoxicity, human toxicity, ototoxicity,phototoxicity o... 

Lee, D-Y, Jung, L, Yoo, K-H, Song, M-C, Chung, I-S, Ahn, E-M, Kim, D-K, Baek, N-I. Cytotoxic sterols from the fruits of Cornus kousa Burg. J. Appl. Biol. Chem., 2008b, 51, 73-75... 

Table I. Cytotoxicities (IC50 nM) of Fluorine Containing Taxoids F-Taxoid AU A549 HT 29 MCF7 MCF7R...

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