Hypoxic cancer cells

Brown JM. Exploiting the hypoxic cancer cell mechanisms and therapeutic strategies. Mol Med Today 2000 6(4) 157-162. 

One-electron reduction potentials have been measured for regioisomer derivatives of 3-nitro-l,2,4-triazoles for the development of new radiosensitizers of hypoxic cancer cells for radiotherapy [989],... 

Solid tumors, because of poor vascularization, generally contain hypoxic cancer cells that are resistant to treatment. PFC emulsions can deliver O2 deep into tumor regions that would otherwise be hypoxic, thereby improving the response of tumor cells to radio and chemotherapy without compromising the tolerance of normal tissues. 

Harada H, Kizaka-Kondoh S, Itasaka S, et al. The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIE-1 activity in tumor xenografts. Biochem Biophys Res Commun 2007 360 791-7%. Inoue M, Mukai M, Hamanaka Y, Tatsuta M, Hiraoka M, Kizaka-Kondoh S. Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites. Int J Oncol 2004 25 713-720. 

The Wnt/P -Catenin Pathway in Breast Cancer and Interactions Between HIF-la and P -Catenin in Hypoxic Cancer Cells... 

Keyes SR, Loomis R, DiGiovanna MP, Pritsos CA, Rockwell S, Sartorelli AC (1991) Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells. Cancer Commun 3(10-11) 351-356... 

Douple EB, Richmond RC. Platinum complexes as radiosensitizers of hypoxic mammalian cells. Br J Cancer 1978 37(Suppl III) 98—102. 

The rate of growth of human and experimental cancers is initially quite rapid (exponential) and then slows until a plateau is reached. The decrease in growth rate with increasing tumor size is related both to a decrease in the proportion of cancer cells actively proliferating (termed the growth fraction) and to an increase in the rate of cell loss due to hypoxic necrosis, poor nutrient supply, immunological defense mechanisms, and other processes. 

Hypoxic cells are present in the malignant tumors they result from the fast proliferation of the cancer cells. 

Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Simioni C, Leung E, Maclennan S, Baraldi PG, Borea PA (2007a) Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-lalpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. Mol Pharmacol 72(2) 395-406... 

Adams, G.E. et al. (1980) Toxicity of nitro compounds toward hypoxic mammalian cells in vitro dependence on reduction potential, J. Nat. Cancer Inst. 64, 555-560. 

Hypoxic mammalian cell radiosensitization by nitric oxide, Cancer Res. S3 5845-5848. 

Kennedy, K. A., Teicher, B. A., Rockwell, S., Sartorelli, A. C. The hypoxic tumor cell a target for selective cancer chemotherapy. Biochem. Pharmacol. 1980, 29, 1-8. 

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