Hypoxia-induced activity

It has been suggested that induction of MKP-1 gene expression occurs as a compensatory response to activation of MAPK (86,87). Although pharmacological blockade of MEK, the upstream activator of MAPK, prevented hypoxia-induced phosphorylation of MAPK (ERKl /2), it did not alter the effect of hypoxia on MKP-1 mRNA levels (81). Therefore, the hypoxia-induced activation of MAPK is... 

Madden J, Dawson C, Harder D. Hypoxia-induced activation in small isolated pulmonary arteries from the cat. J Appl Physiol 1985 59 113-118. 

Interestingly, Gassman and co-workers have demonstrated that the regulation of the induction of AHR by indolo[3,2-/)]carbazole (4) was reduced by prior activation of the hypoxia-inducible expression. As the hypoxia pathways are dependent on ARNT, prior activation may deplete the cell of available ARNT for AHR heterodimerization (97MI3). 

Ahn JK, Koh EM, Cha HS, Lee YS, Kim J, Bae EK (2008) Role of hypoxia-inducible factor-lalphain hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-tike synoviocytes. Rheumatology (Oxford) 47(6) 834-839 Ao X, Wang X, Lennartz MR, Loegering DJ, Stenken JA (2006) Multiplexed cytokine detection in microUter microdialysis samples obtained from activated cultured macrophages. J Pharm Biomed Anal 40(4) 915-921... 

Zhou YD et al (2005) Terpenoid tetrahydroisoquinoline alkaloids emetine, king me. and isocephae-line inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells. J Nat Prod 68(6) 947-950... 

TF transcription factor, R receptor, Fur ferric uptake regulation protein, NF-kB nuclear factor-kB, AP-1 activator protein-1, Egr-1 early growth response-1, VDR la,25-dihydroxy-vitamin D3 receptor, RXR retinoid X receptor, PPARy peroxisome proliferator-activated receptor y NFAT nuclear factor of activated T-cells, HSF heat shock factor, p53 tumor suppressor p53, HIF-1 hypoxia inducible factor-1. ... 

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