Hyperuricemia conditions associated with

Hyperuricemia may be an asymptomatic condition, with an increased serum uric acid concentration as the only apparent abnormality. A urate concentration greater than 7.0 mg/dL is abnormal and associated with an increased risk for gout. 

Therapeutic uses Allopurinol is effective in the treatment of primary hyperuricemia of gout and hyperuricemia secondary to other conditions, such as that associated with certain malignancies (those in which large amounts of purines are produced) or in renal disease. 

The term gout describes a disease spectrum including hyperuricemia, recurrent attacks of acute arthritis associated with monosodium urate crystals in leukocytes found in synovial fluid, deposits of monosodium urate crystals in tissues (tophi), interstitial renal disease, and uric acid nephrolithiasis. Hyperuricemia may be an asymptomatic condition, with an increased serum uric acid concentration as the only apparent abnormality. A urate concentration greater than 7.0 mg/dL is abnormal and associated with an increased risk for gout. 

Several enzyme therapies are also used in the treatment of cancer. For instance, rasburicase (uricase Elitek EC 1.7.3.3) is used in the treatment of hyperuricemia due to tumor lysis syndrome (TLS). This is a potentially life-threatening condition that is associated with rapidly developing tumors, such as those found in lymphoma and leukemia, in patients undergoing chemotherapy. The incidence of hyperuricemia in these patients is close to 20% [88]. Uricase is an interesting enzyme, because it is found in most mammals, with the exception of humans, where the gene contains a nonsense mutation [89]. Rasburicase is well tolerated, has a very fast onset of action, and is administered intravenously once a day. However, the enzyme cannot be used on patients with glucose-6-phosphate dehydrogenase deficiency [90]. The... 

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