Hypertriglyceridemia

The primary care provider prescribes fenofibrate (Tricor) for the treatment of hypertriglyceridemia. The patient is now taking 200 mg/d PO. Is this an appropriate dosage If not, what action would you take If the dose is appropriate, how many capsules would you administer if the drugis available in 54-mg capsules ... 

O In the Western hemisphere, acute pancreatitis is caused mainly by ethanol use/abuse and gallstones. Other common causes of acute pancreatitis include hypertriglyceridemia, endoscopic retrograde cholangiopancreatography (ERCP), and autodigestion due to early activation of pancreatic enzymes. Numerous medications have also been implicated as causes of acute pancreatitis (Table 20-1). 

Other possible laboratory abnormalities include elevated white blood cell count, hyperglycemia, hypocalcemia, hyperbilirubinemia, elevated serum lactate dehydrogenase (LDH), and hypertriglyceridemia. 

Hypertriglyceridemia or significant family history of Aripiprazole, ziprasidone Risperidone, quetiapine... 

Hypertriglyceridemia Reversible when drug discontinued or dose decreased... 

Intravenous lipid emulsions are also a source of calories. The typical daily dose in adults is approximately 0.5 to 1 g/kg per day. In the absence of hypertriglyceridemia, substituting a portion of dextrose calories with lipid calories may be beneficial in situations where dextrose infusion may lead to complications (e.g., hyperglycemia). Some examples include patients with diabetes mellitus or pancreatic disease and patients under severe stress (e.g., trauma or burns) who are at risk for hyperglycemia. The maximum of dose of lipid emulsions is 2.5 g/kg per day,7 or 60% of total daily calories, although doses this high are used rarely in practice. 

Dextrose Hyperglycemia, hypertriglyceridemia, hepatic steatosis, hypercapnia hyperglycemia may cause fluid and electrolyte disturbances and increased infection risk... 

Zocor (Simvastatin) Hypercholesterolemia Hyperlipoproteinemia Hypertriglyceridemia 3.9 1.3 1989 - UK 1991 - US Once daily... 

BARs are not used as first-line therapy if triglycerides are elevated at baseline because hypertriglyceridemia may worsen with a BAR alone. 

The principal use of niacin is for mixed hyperlipidemia or as a second-line agent in combination therapy for hypercholesterolemia. It is a first-line agent or alternative for the treatment of hypertriglyceridemia and diabetic dyslipidemia. 

Fish oil supplementation may be most useful in patients with hypertriglyceridemia, but its role in treatment is not well defined. 

Treatment of type I hyperlipoproteinemia is directed toward reduction of chylomicrons derived from dietary fat with the subsequent reduction in plasma triglycerides. Total daily fat intake should be no more than 10 to 25 g/day, or approximately 15% of total calories. Secondary causes of hypertriglyceridemia should be excluded, and, if present, the underlying disorder should be treated appropriately. 

Lipoprotein pattern types I, III, IV, and V are associated with hypertriglyceridemia, and these primary lipoprotein disorders should be excluded prior to implementing therapy. 

Diabetic dyslipidemia is characterized by hypertriglyceridemia, low HDL, and minimally elevated LDL. Small, dense LDL (pattern B) in diabetes is more atherogenic than larger, more buoyant forms of LDL (pattern A). 

Women with migraine headaches, history of thromboembolic disease, heart disease, cerebrovascular disease, SLE with vascular disease, and hypertriglyceridemia are good candidates for progestin-only methods (e.g., minip-ills, DMPA, and the levonorgestrel intrauterine system). Women older than 35 years who are smokers or are obese, or who have hypertension or vascular disease, should use progesterone-only methods. 

Does the patient have hypertriglyceridemia or type 2 diabetes mellitus ... 

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