Lactate dehydrogenase serum

Other possible laboratory abnormalities include elevated white blood cell count, hyperglycemia, hypocalcemia, hyperbilirubinemia, elevated serum lactate dehydrogenase (LDH), and hypertriglyceridemia. 

J2. Jorgensen, C. R., Zimmerman, T. S., and Wang, Y., Serum lactate dehydrogenase elevation in ambulatory cardiac patients Evidence for chronic hemolysis. Circulation 35, 79-89 (1967). 

Examination of these people revealed disruptions in bone marrow function, including cases of hypoplastic, acellular, hyperplastic, or normoblastic bone marrow. The continuing assessment further identified that ineffective erythropoiesis or increased hemolysis may have been responsible for the reticulocytosis, hyperbilirubinemia, erythroblastemia, increase in quantitative osmotic fragility, and elevated serum lactate dehydrogenase levels observed in some patients. 

Drent M, Cobben NA, Van Dieijen-Visser MP, Braat SH, Wouters EF. Serum lactate dehydrogenase activity indicator of the development of pneumonitis induced by amiodarone. Eur Heart J 1998 19(6) 969-70. 

The transient and moderate rises in leukocyte alkaline phosphatase and uric acid serum concentrations that are often observed after G-CSF treatment are considered to arise from an increased neutrophil count (SEDA-17, 396). Similarly, serum lactate dehydrogenase and alkaline phosphatase activities are often increased, and this should be interpreted as the consequence of enzyme release after growth factor-induced leukocyte recovery (SED-13, 1115). 

Since NADPH absorbs light at 340 nm and NADP+ does not (Figure 8-3), this reaction can be followed by measurement of the change in absorbance at this wavelength with time. A similar assay (with lactate and NAD+) can be used for serum lactate dehydrogenase. The difference in absorbance is measured so readily that a number of assays make use of it directly or indirectly. In the latter case, the reaction to be measured is linked by one or more steps to a reaction in which a nicotinamide adenine dinucleotide is oxidized or reduced. Thus, in the measurement of aminotransferases (Chapter 17), one of the products of the primary reaction serves as a substrate for a secondary reaction in which NADH is required. For example, in the assay of aspartate aminotransferase,... 

Itoh, R., and H. K. Ozasa. 1985. Changes in serum lactate dehydrogenase isozyme X activity observed after cadmium administration. Toxicology Letters 28 151-154. 

Hepatitis and, rarely, liver abscess also occur. Mild elevations of serum lactate dehydrogenase and alkaline phosphatase are common. Biopsy may show well-formed granulomas or nonspecific hepatitis with collections of mononuclear cells.32... 

Chan, W.Y., T.B. Ng, J.L. Lu, et al. 1995. Effects of decoctions prepared from Aconitum carmichaeli, Aconitum kusnezoffii and Tripterygium wilfordii on serum lactate dehydrogenase activity and histology of liver, kidney, heart and gonad in mice. Hum. Exp. Toxicol. 14(6) 489-493. 

Seki K, Hoshihara T, Nagata I (1992) Leiomyosarcoma of the uterus ultrasonography and serum lactate dehydrogenase level. Gynecol Obstet Invest 33 114-118... 

A 46-year-old cocaine user developed constant bilateral flank pain that worsened with deep inspiration. He had a sinus tachycardia and right upper quadrant tenderness. His D-dimers and serum lactate dehydrogenase activity were raised and there was cocaine in the urine. An abdominal CT scan showed bilateral renal infarcts. He was anticoagulated. 

Elevated serum lactate dehydrogenase (LX)H) and surfactant proteins (SP-A and SP-D) Neutrahzing autoantihodies to granulocyte/macrophage colony-stimulating factor (GM-CSF)... 

Serum lactate dehydrogenase (LDH) is elevated in 80% of patients with iPAP (1,4,5,11,32). Concentrations of carcinoembryonic antigen (CEA) (5), cytoker-atin (11), Kreb von den Lungen-6 (KL-6), a mucin-like protein secreted by type 11 pneumocytes (35-37), and surfactant proteins-A (SP-A) and SP-D (37 0) are elevated in serum and BALE in iPAP. However, these various laboratory findings are not specific for PAP (5,40). 

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