Hypertriglyceridemia isolated

Colestipol, cholestyramine, and colesevelam are useful only for isolated increases in LDL. In patients who also have hypertriglyceridemia, VLDL levels may be further increased during treatment with resins. 

Low-dose bezafibrate was associated with myositis in a patient with mild chronic renal insufficiency (serum creatinine 210 pmol/l) (59). She was a 58-year-old obese diabetic with isolated hypertriglyceridemia. 

In the pathogenesis of nephrotic hyperlipidemia, both increased production and impaired catabolism of lipoproteins were demonstrated to play a role. Pathogenic mechanisms may be different in nephrotic patients with isolated hypercholesterolemia and in patients with combined hypercholesterolemia and hypertriglyceridemia (V6). 

The study depicted in Figure 6.33 illustrates the attack of lipase on VLDLs isolated from the plasma of normal subjects and from patients suffering from hyperhriglyceridemia. The VLDI.S from the normal subject would be expected to contain TCs as well as apo C-tl. Those from the patient with hypertriglyceridemia... 

Asymptomatic rises in pancreatic enzymes and reversible acute pancreatitis have been reported in isolated patients, with no mention of hypertriglyceridemia (SEDA-19,336). 

Treatment a statin or a combination of a statin and ezetimibe for raised isolated hypercholesterolaemia or combined dyslipidaemia fibrates and/or high doses of omega-3 fatty acids (2 g x 2 daily) in isolated fasting hypertriglyceridemia (>3.4 mmol/L or... 

The values are means SD CHD, coronary heart disease DM, diabetes mellitus MS, metabolic syndrome IHTG, isolated hypertriglyceridemia CHL, combined hyperlipidemia CE, cholesterol esters PL, phospholipids FA, fatty acid Er, erythrocytes IR,msulm resistence NGT, normal glucoso tolerance. 

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