Hypersensitivities risk factor

Walusiak, J. et al., The risk factors of occupational hypersensitivity in apprentice bakers the predictive value of atopy markers, Int. Arch. Occup. Environ. Health, 75 Suppl, SI 17, 2002. 

Demoly, P. and Rebelo Gomes, E., Drug hypersensitivities definition, epidemiology and risk factors, Eur. Ann. Allergy Clin, Immunol., 37, 202, 2005. 

A. The NRTIs can produce a potentially fatal syndrome of lactic acidosis and severe hepatomegaly with hepatic steatosis. Risk factors associated with the development of this syndrome include female sex, obesity, alcoholism, and prolonged exposure to NRTIs. Peripheral neuropathy is a common side effect of some NRTIs (e.g., stavudine., didanosine, and zalcitabine) but not associated with these risk factors. Stevens-Johnson syndrome is rarely associated with NNRTIs, such as nevirapine, and not with these risk factors. Hyperuricemia is not associated with these risk factors. Hypersensitivity reaction may oc-... 

Symonds W, CutreU A, Edwards M, Steel H, Spreen B, Powell G, McGuirk S, Hetherington S. Risk factor analysis of hypersensitivity reactions to abacavir. Clin Ther 2002 24(4) 565-73. 

Suzuki Y, Inagi R, Aono T, Yamanishi K, Shiohara T. Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 1998 134(9) 1108-12. 

No specific risk factors have been identified because these are idiosyncratic hypersensitivity reactions. Individuals with other drug allergies may have increased risk and warrant close monitoring. 

Gugliehni L, Gugliehni P, Demoly P (2006b) Drug hypersensitivity epidemiology and risk factors. Cuir Pharm Des 12 3309-3312... 

Moneret-Vautrin DA, Beaudouin E, Widmer S, Mouton C, Kanny G, Prestat F, Kohler C, Feldmann L (1993) Prospective study of risk factors in natural rubber latex hypersensitivity. J Allergy Clin Immunol 92 668-677 Morales C, Basomba A, Carreira J, Sastre A (1989) Anaphylaxis produced by rubber glove contact case reports and immunological identification of the antigens involved. Clin Exp Allergy 19 425-430... 

Although propofol is generally said to be a remarkably safe dmg, 14 patients were reported to have life-threatening reactions within a few minutes of the administration of propofol, numerous other anaphylactic-like reactions have been reported, and other occasionally observed hypersensitivity reactions include bronchospasm, angioedema, urticaria, and erythematous rash. The overall incidence of anaphylaxis induced by propofol in France is about 1 % and 0.65 % in the Australian survey (Table 7.1). Another survey estimated that 1.2 % of cases of perioperative anaphylactic shock were attributable to propofol. Risk factors for a reaction are said to be a history of previous dmg allergy and the use with atracu-rium, the latter because of possibly enhanced histamine release. 

Risk factors for a late skin reaction following administration of an iodinated contrast medium include current and up to 2 years past treatment with interleukin-2 (IL-2), a history of drug allergy or contact hypersensitivity, and a history of reaction to a previous contrast medium. Late reactions are more conunon in patients who reacted previously, especially if the same contrast medium is administered (see below). The latter fact is interesting since it suggests that the mechanism of the late reaction with its demonstration of memory may be immunologically and, in particular, T cell mediated. 

Patients allergic to a CS often react to multiple allergens, but it remains unclear whether atopy is a risk factor for CS hypersensitivity. A history of atopy was found in 34 % of the 315 CS-allergic patients but overall, it is difficult to determine whether a higher incidence is dne to increased susceptibility or greater exposure. Few reactions in asthmatics have been noted despite the extremely widespread nse of inhaled CSs. Risk factors for systemic sensitivity do not seem to have been stndied bnt some reports indicate a higher incidence in asthmatic subjects. 

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