8- Hydroxyquinoline 8- quinolinol

Z. Bouhsain, S. Garrigues, A. Morales-Rubio, M. de la Guardia, Flow injection spectrophotometric determination of paracetamol in pharmaceuticals by means of on-line microwave-assisted hydrolysis and reaction with 8-hydroxyquinoline (8-quinolinol), Anal. Chim. Acta 330 (1996) 59. 

Hydroxyquinolines (Quinolinols). A number of methods have been employed for their preparation. A modified Chichibabia reaction of quinoline ia fused KOH—NaOH at 240°C produces 70% of 2-hydroxyquiQoline [59-31-4] (121). Alternative names based on the facile keto—enol tautomerism of two of these compounds are 2(1H) and 4(lJd)-quiQolinone none of the other quinolinols show this property. The treatment of... 

Copper quinolinolate (oxine copper) is the chelate of divalent copper and 8-hydroxyquinoline and shares most of its market with copper naphthenate, which is a complex copper salt of mixed naphthenic acids. The principal uses are in wood treatments and some military textiles, where the green color is not objectionable. Copper naphthenate has an odor but is cheaper than oxine. Both copper naphthenate and 2inc naphthenate have performed well in environment tests, with exposure to soil above-ground, as well as concrete (33). 

Steric Selectivity. In addition to the normal regularities that can be rationalized by electronic considerations, steric factors are important in coordination chemistry. To illustrate, 8-hydroxyquinoline, or 8-quinolinol (Hq) [148-24-3J, at 100°C precipitates both Mg " and AE" from aqueous solution as hydrated Mg(q)2 (formulated as Mg(q)2(H20)2 [56531 -18-1]) and as Al(q)3 [2085-33-8] respectively. 2-Meth54-8-hydroxyquinohne [826-81-3] (6),... 

Certain halogen derivatives of 8-hydroxyquinoline have a record of therapeutic efficacy in the treatment of cutaneous fungus infections and also of amebic dysentery. Among these are 5-chloro-7-iodo-8-quinolinol [130-26-7] (iodochlorhydroxyquin, Vioform), 5,7-diiodo-8-hydroxyquinoline [83-73-8] (diiodohydroxyquin), and sodium 7-iodo-8-hydroxyquinoline-5-sulfonate [885-04-1] (chiniofon) (196—198). 

Hydroxyquinoline (oxine, 8-quinolinol) [148-24-3] M 145.2, m 71-73 , 75-76 , 76 , b 267 pKj 4.91, pK 9.81. Crystd from hot EtOH, acetone, pet ether (b 60-80 ) or water. Crude oxine can be purified by pptn of copper oxinate, followed by liberation of free oxine with H2S or by steam distn after acidification with H2SO4. Stored in the dark. Forms metal complexes. [Manske et al. Can J Research 27F 359 1949 Phillips Chem Rev 56 271 1956.]... 

Iodoquinol Iodoquinol, 5,7-diiodo-8-quinolinol (37.2.2), is made by iodination of 8-oxyquinoline (37.2.1) using a mixture of potassium iodide/potassium iodate. The initial 8-hydroxyquinolin (37.2.1) is made from 2-aminophenol and glycerol in the presence of sulfuric acid and nitrobenzene (Skraup synthesis) [39,40]. 

Acetic acid - 8-hydroxyquinoline reagent - dissolve 10 g 8-hydroxy-quinoline in a solution of 2.5 % (v/v) acetic acid and make up to 1 I. (The 8-hydroxyquinoline blocks the readsorption or precipitation of phosphate by active iron and aluminium during acetic acid extraction. Synonyms hydroxybenzopyridine oxine phenopyridine 8-quinolinol. Not carcinogenic, but may be harmful if swallowed, and causes irritation to eyes, respiratory tract and skin safety data sheet at http //www. jtbaker.com/msds/q7250. htm.)... 

Catalyst] = [substrate] = 1.00 X 10 3 M. b Second-order rate constants (reactions first-order in substrate and first-order in catalyst). c First-order, sec.-1 (substrate only) d SA2 = salicylate anion. Tiron"4 = 3,5-disulfopyrocatechol anion. f HQS 2 = 5-sulfo-8-quinolinol anion. 0 SSA 3 = 5-sulfo-8-hydroxyquinoline anion. 

Quinolinol (mixture of 57-74% 5,7-dichloro-8-hydroxyquinoline, 23-40% 5-chloro-8-hydroxyquinoline and less than 3% 7-chloro-8-hydroxyquinoline) was synthesized by interaction of 8-hydroxyquinoline with sulfuryl chloride in glacial acetic acid at 50°C for 1.5 hours. The reaction mixture was cooled, pH was made 6.0 (by addition NH4OH). The suspension obtained was centrifuged, washed with water and the mixture of chlorohydroxyquinolines was dried. 

SYNS BIOQUIN BIOQUIN 1 BIS(8-QUINOUNATO)COPPER BIS(8-QUINOLINOL-ATO)COPPER BIS(8-QUINOLINOLATO-NLo )-COPPER CELLU-QUIN COPPER-8 COPPER HYDROXYQUINOLATE COPPER-8-HYDROXY-QUINOLATE COPPER-8-HYDROXYQUINOLINATE COPPER-8-HYDROXYQUINOLINE COPPER OXINATE COPPER (2-I-) OXINATE COPPER OXINE... 

SYNS DIIODOHYDROXYQUIN DIIODOHYDROXYQUINOLINE 5,7-DIIODO-8-HYDROXYQUINOLINE 5,7-DIIODO-OXINE DIIODOQUIN 5,7-DIIODO-8-QUINOLINOL DINOLELNE DIODOQUIN DIODOXYLIN DI-QUINOL DIREXIODE DISOQUIN DYODIN EMBEQLTN ENTEROSEPT FLORAQUIN FLUORAQUIN 8-HYDROXY-5,7-DIIODOQUINOLINE lODOQUINOL lOQUIN SUSPENSION LANODOXIN MOEBIQUIN QUINADOME SEARLEQUIN SEBAQUIN SS 578 YODOXIN ZOAQUIN... 

SYNS ARTHO LM LIQUI-SAN LM SEED PROTECTANT METASOL METAZOL 8-(METHYLMERCURIOXY)QUINOLINE METHYLMERCURY (3-HYDROXYQUINOLATE METHYLMERCURY 8-HYDROXYQUINOLINATE Q METHYLMERCURY OXINATE METHYLMERCURY OXYQUINOLINATE ORTHO-LM APPLE SPRAY ORTHO LM CONCENTRATE ORTHO LM SEED PROTECTANT 8-(QUINOLINOLATO)METHYL MERCURY 8-QUINOLINOL, MERCURY COMPLEX... 

Hydroxyquinoline or 8-Quinolinol, oxyquinoline or Oxine (Called 8-Oxy-chinolin or Chino phenol in Ger). 

Very favourable hydrogen bonding may occur in substituted 8-hydroxyquinoline N-oxides (substituted 32) judging from the 50H value (in the 5,7-dinitro-8-quinolinol N-oxide a value of 20.38 ppm is found) as well as the deuterium isotope effects on the C chemical shifts. Complicated substituent effects are found, because substiments such as bromine may interact with both the OH and the N—O group. No tautomerism was observed... 

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