4-Hydroxymethyl-2-isopropyl

Bis-[ 1-ethyl-propyloxy]- XII/2, 291 Bis-[2-ethylthio-ethoxyJ- XII/2, 27 Bis-fferrocenylmethoxy]- El, 331 Bis-[2-fluor-ethoxy]- XII/2, 24 Bis-[l-hydroxy-benzyl]-isopropyl- XII/1, 157 Bis-f2-hydroxy-ethoxy]- XII/2, 21 Bis-[2-hydroxy-ethyl]-hydroxymethyl- E2, 54 Bis-[hydroxymethyl]-cyclohexyl- E2. 53 Bis-[hydroxymethyl]-isopropyl- E2, 53 Bis-[hydroxymethyl]-methyl- XII/1, 142 E2, 48,... 

Ethoxy-methyl)-methyl- E14a/2, 95 (Cl - NR-N02) Hydroxymethyl-isopropyl- E14a/2, 73 (NH -> NH-CH2-OH) Ethyl-(methoxy-methyl)- E14a/2, 95 (Cl - NR-N02)... 

Carbazole, 2-hydroxy-reactions with citral, 4, 235 Carbazole, 2-hydroxy-9-methyl-synthesis, 4, 294 Carbazole, N-hydroxymethyl-as metabolite of carbazole, 1, 230 Carbazole, N-isopropyl-PE spectroscopy, 4, 190 Carbazole, A7-methyl- N NMR, 4, 175 X-ray spectroscopy, 4, 163 Carbazole, 1-nitro-synthesis, 4, 282 Carbazole, tetrahydro-dehydrogenation, 4, 282, 312 synthesis, 4, 107, 337, 353 Carbazole, 1,2,3,4-tetrahydro-reduction, 4, 255, 256 synthesis, 4, 312, 325, 352 Carbazole, 1,2,3,4-tetrahydro-1 -oxo-synthesis, 4, 337 Carbazole, 9-trifluoroacetyl-synthesis, 4, 218 Carbazole, vinyl-polymers, 1, 275, 301 Carbazole, 9-vinyl-copolymer... 

Imidazole, 5-hydroxy-1 -isopropyl-2-methyl-4-propyl-synthesis, S, 475 Imidazole, 2-hydroxymethyl-hydroxymethylation, S, 404 oxidation, S, 430 Imidazole, 4-hydroxymethyl-oxidation, S, 430 synthesis, S, 480, 484 Imidazole, 2-hydroxymethyl-4-methyl-synthesis, S, 484... 

For laminating, the ammonia-catalysed resins are usually dissolved in industrial methylated spirits (IMS) or, less commonly, isopropyl alcohol. Resins which have a high hydroxymethyl content (i.e. made by using a high ratio of... 

A solution of 1.7 g of 2-hydroxymethyl-3-benzyloxy-(1-hydroxy-2-tert-butyl-aminoethyl)py-ridine in 30 ml of methanol containing 1.2 ml of water is shaken with 700 mg of 5% palladium-onatmospheric pressure. In 17 minutes the theoretical amount of hydrogen has been consumed and the catalyst is filtered. Concentration of the filtrate under reduced pressure provides 1.4 g of the crude product as an oil. Ethanol (5 ml) Is added to the residual oil followed by 6 ml of 1.75N ethanolic hydrogen chloride solution and, finally, by 5 ml of Isopropyl ether. The precipitated product is filtered and washed with isopropyl ether containing 20% ethanol, 1.35 g, melting point 182 (dec.). 

El-3-r/ ethyl-1,3-pentadiene (E)-1 -Bromo-2-isopropyl-1,3-butadiene (Z)-2-Hydroxymethyl-2-butenoic acid... 

OH H3C°tyS HjCO- i COOH CH(CH3)2 1 -Hydroxy-6,7-dimethoxy-3-hydroxymethyl-5-isopropyl-naphthalin 93 207-209 3... 

Dimethyl peroxide Diethyl peroxide Di-t-butyl-di-peroxyphthalate Difuroyl peroxide Dibenzoyl peroxide Dimeric ethylidene peroxide Dimeric acetone peroxide Dimeric cyclohexanone peroxide Diozonide of phorone Dimethyl ketone peroxide Ethyl hydroperoxide Ethylene ozonide Hydroxymethyl methyl peroxide Hydroxymethyl hydroperoxide 1-Hydroxyethyl ethyl peroxide 1 -Hydroperoxy-1 -acetoxycyclodecan-6-one Isopropyl percarbonate Isopropyl hydroperoxide Methyl ethyl ketone peroxide Methyl hydroperoxide Methyl ethyl peroxide Monoperoxy succinic acid Nonanoyl peroxide (75% hydrocarbon solution) 1-Naphthoyl peroxide Oxalic acid ester of t-butyl hydroperoxide Ozonide of maleic anhydride Phenylhydrazone hydroperoxide Polymeric butadiene peroxide Polymeric isoprene peroxide Polymeric dimethylbutadiene peroxide Polymeric peroxides of methacrylic acid esters and styrene... 

This stereospecific oxidation does not occur for all dioximes, probably due to isomerisation of the dioxime during the reaction or to different reaction mechanisms involved in the use of different oxidants. When the lipophilic-hydrophilic balance of the two furoxan isomers is appropriate, they are easily separated by chromatography or fractional crystallisation. For example, the synthesis of 4-hydroxymethyl-3-furoxancarboxamide (CAS 1609), one of the most promising furoxancarboxamide vasodilators (see later), passes through the intermediate formation of a mixture of the two isomeric methyl hydroxymethylfuroxancarboxylic esters, which can easily be separated by recrystallisation from isopropyl acetate [18]. 

Cyclopropanation is an important synthetic method, and enantioselective catalytic reactions of olefins and diazoacetates provide access to valuable products with biological activity. In general, these reactions are conducted in anhydrous solvents and in several cases water was found to diminish the rate or selectivity (or both) of a given process. Therefore it came as a surprise, that the Cyclopropanation of styrene with (+)- or (-)-menthyl diazoacetates, catalyzed by a water-soluble Ru-complex with a chiral bis(hydroxymethyldihydrooxazolyl)pyridine (hm-pybox) ligand proceeded not only faster but with much Wgher enantioselectivity (up to 97 % e.e.) than the analogous reactions in neat THF or toluene(8-28 % e.e.) (Scheme 6.34) [72]. The fine yields and enantioselectivities may be the results of an accidental favourable match of the steric and electronic properties of hm-pybox and those of the menthyl-dizaoacetates, since the hydroxyethyl or isopropyl derivatives of the ligand proved to be inferior to the hydroxymethyl compound. Nevertheless, this is the first catalytic aqueous cyclopropanation which may open the way to other similar reactions in aqueous media. 

Gemfibrozil is absorbed quantitatively from the intestine and is tightly bound to plasma proteins. It undergoes enterohepatic circulation and readily passes the placenta. The plasma half-life is 1.5 hours. Seventy percent is eliminated through the kidneys, mostly unmodified. The liver modifies some of the drug to hydroxymethyl, carboxyl, or quinol derivatives. Fenofibrate is an isopropyl ester that is hydrolyzed completely in the intestine. Its plasma half-life is 20 hours. Sixty percent is excreted in the urine as the glucuronide, and about 25% in feces. 

Oxidation of 8-hydroxymethyl-2-isopropyl-l 1 //-pyrido[2,l-b]quinazolin-11-one with pyridinium chlorochromate in methylene chloride gave the 8-carboxaldehyde, which was converted into its 8-aminomethyl derivatives by reacting with amines followed by reduction of the Schiff bases with sodium cyanoborohydride in acetic acid (87JOC2469). 

N-(Hydroxymethyl)acrylamide (HMA, Tokyo Kasei Co.) was recrystallized from ethyl acetate. N,N-Dimethylacrylamide (DMA, Tokyo Kasei Co.) and styrene (St, Kashima Kagaku Yakuhin Co.) were distilled at 54°C/3.5 mmHg and 40°C/14.5 mmHg, respectively. In some copolymerizations cross-linking reagents were added to reduce the formation of water-soluble polymer. N -Methylenebisacrylamide (MBA, Nakarai Chemicals Co.) and N-allylacrylamide (AAA, Polysciences, Inc.) were used as received. Divinylbenzene (DVB, Tokyo Kasei Co.) was treated with 10 % sodium hydroxide and dried. Two kinds of initiators were used Potassium persulfate (KPS, Taisei Kagaku Co.) was recrystallized from water and azobis(isopropyl-... 

The C-C bonding in R2 has been replaced by ether, thioether, amide or ester bond without losing sweetness. Rx is a small side chain such as a methyl, ethyl, isopropyl, or hydroxymethyl group, or an ester having a small substituent. The exact chemical nature of these groups is not crucial. 

Method. To 200 p, of the plasma sample in a 10-ml conical test-tube add 40 p,l of 2M tris(hydroxymethyl)methylamine and 4ml of a mixture of chloroform and isopropyl alcohol (3 1) mix for 30 seconds, and centrifuge for 5 minutes. Carefully transfer the solvent layer to a second test-tube containing 4 ml of 0.05M sulphuric acid, mix, cenhifuge for 5 minutes, and carefully hansfer about 2ml of die acid layer to a 1-cm quartz fluorescence cuvette. Excite the extract at 350 nm and measure the intensity of emission at 450 nm. The standard plasma solutions are processed similarly at the same time. 

Hydroxymethyl-l-isopropyl-2-oxo-E17e, 186/266 (2-CycIopropyli-den-alkanol/TiX4/R—O — OH)... 

Cyclobutan 2,2-Dimethyl-3-hydroxymethyl-1 -isopropyl -E17e, 397 (S02 Ar - H) Cycloheptan 3-Hydroxy-l,l,4-trimethyl- Vl/la, 2, 819 Cyclohexan... 

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