4-Hydroxybenzoic acid benzyl ester

Abbreviations ACP, cross-linked polysaccharide of hyaluronic acid ALAFF, polymer of an ester of alginic acid CBZ, carbamazepine PEG, polyethylene glycol DCM, dichloromethane DMF, dimethylformamide DMSO, dimethyl sulfoxide NMP, A/-methylpyrrolidone P-HBA, p-hydroxybenzoic acid HYAFF-1, hyaluronic acid benzylic ester PEG-PLA, poly(ethylene glycol)-poly(L-lactide) PLGA, poly(lactic-co-glycolide) acid. 

Benzyl Salicylate, 2-Hydroxybenzoic acid phenyl methyl ester salicylic acid benzyl ester. CKH mol wt 228.24. C 73.677°, H 5.307°, O 21.03%. Prepd from sodium alkylate and benzyl chloride Volwiler, Vliet, J. Am. Chem. See 43, 1672 (1921). 

Beilstein Handbook Reference) AI3-00517 Benzoic acid, 2-hydroxy-, phenylmethyl ester Benzyl 0-hydroxybenzoate Benzyl s icylate BRN 2115365 CCRIS 4749 EINECS 204-262-9 FEMA No. 2151 NSC 6647 Phenyinnethyl 2-hydroxybenzoate Salicylic acid, benzyl ester licylsaeurebenzylester SalicylsOurebenzylester. Solid bp = 320° d2 = 1.1799 Am = 238, 306 nm (e = 10700, 4550, MeOH) slightly soluble in H2O, soluble in EtOH, EtzO, CCI4. 

Synonyms 2-hydroxybenzoic acid phenylmethyl ester salicylic acid benzyl ester benzyl o-hydroxybenzoate 2-hydroxybenzoic acid phenyl methyl ester... 

Perfumes, Flavors, Cosmetics, and Soap. Many naturally occurring esters in essential oils and some synthetic esters are important fragrance and flavor compounds (61,62). They are used in perfumes, flavors, cosmetics, soaps, detergents, and air fresheners. Benzyl, butyl, ethyl, methyl, and phenyl esters of benzoic acid are used as flavors, perfumes, and food preservatives. Glyceryl 4-aminobenzoate [136-44-7] and 2-ethyUiexyl 4-dimethylaminobenzoate [21245-02-3] are used in cosmetic sunscreen preparations. Alkyl esters of 4-hydroxybenzoic acid, called parabens, have been used under various names for fungus infections of the skin, and as preservatives in lotions and creams (101). Soap and cosmetic fragrances use large amounts of amyl and benzyl saHcylate. Benzyl saHcylate [118-58-1] is also used in deodorant sprays. 2-Ethylhexyl saHcylate [118-60-5] and 2-ethylhexyl 4-methoxycinnamate [5466-77-3] are used in sunscreen formulations (102). 

Photolytic. Photolysis of permethrin in aqueous solutions containing various solvents (acetone, hexane, and methanol) under UV light (1 >290 nm) or on soil in natural sunlight initially resulted in the isomerization of the cyclopropane moiety and ester cleavage. Photolysis products identified were 3-phenoxybenzyldimethyl acrylate, 3-phenoxybenzaldehyde, 3-phenoxybenzoic acid, mono-chlorovinyl acids, cis- and fra/is-dichlorovinyl acids, benzoic acid, 3-hydroxybenzoic acid, 3-hydroxybenzyl alcohol, benzyl alcohol, benzaldehyde, 3-hydroxybenzaldehyde, and 3-hydroxybenzoic acid (Holmstead et ah, 1978). 

AI3-02955 Benzoic acid, 4-hydroxy-, phenylmethyl ester Benzoic acid, p-hydroxy-, benzyl ester Benzyl 4-hydroxybenzoate Benzyl p-hydroxybenzoate Benzyl parahydroxybenzoate Benzyl Parasept Benzyl Tegosept Benzylparaben EINECS 202-311-9 Nipabenzyl NSC 8080 Parosept Phenylmethyl 4-hydroxybenzoate Solbrol Z. Among the most widely used preservatives in food, drugs, and cosmetics. Preservative, bactericide, fungicide for pharmaceuticals, cosmetics, foods, medicinal preparations, industrial applications. Crystals mp = 110-112°. Nipa. 

CAS 94-18-8 EINECS/ELINCS 202-311-9 Synonyms Benzoic acid, 4-hydroxy-, phenyl methyl ester Benzyl 4-hydroxybenzoate Benzyl p-hydroxybenzoate Phenylmethyl 4-hydroxybenzoate Definition Ester of benzyl alcohol and p-hydroxybenzoic acid Empirical C14H12O3 Toxicology TSCA listed Uses Preservative, bactericide, fungicide for foods, pharmaceuticals, industrial applies. antimicrobial in cosmetics Regulatory BP compliance Manuf./Distrib. Aldrich http //www.sigma-aldrich.com-, Alfa Aesar http //www.aifa.com-, Archimica Inc http //www.archimica.com-. 

Alkyl esters (methyl, ethyl, propyl and heptyl esters, previously also benzyl ester) of p-hydroxybenzoic (4-hydroxybenzoic) acid are... 

The parabens are a class of 4-hydroxybenzoic acid esters (primarily methyl, ethyl, propyl, and butyl esters) that are used as biological preservatives in liquid and semisolid dosage forms.Another preservative often used is benzyl alcohol. Parabens and benzyl alcohol are compendial items. These materials are very stable... 

Buffers can also be provided in parenteral formulations to ensure the required pH needed for solubility and/or stability considerations. Other excipients included in parenteral products are preservatives (e.g., benzyl alcohol, p-hydroxybenzoate esters, and phenol), antioxidants (e.g., ascorbic acid, sodium bisulfite, sodium metabisulfite, cysteine, and butyl hydroxy anisole), surfactants (e.g., polyoxyethylene sorbitan monooleate), and emulsifying agents (e.g., polysorbates). An inert gas (such as nitrogen) can also be used to enhance drug stability. Stability and solubility can also be enhanced by the addition of complexation and chelating agents such as the ethylenediaminetetraacetic acid salts. For a more detailed list of approved excipients in parenteral products, the reader should consult the monographs within the USP. 

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