2- Hydroxy-1 -isopropylamino

Cyclopropan 2-Hydroxy-1-isopropylamino- E16d, 1124 (Oxiran -f Amin)... 

Stability Very stable over several years of shelf life, under normal illumination and extreme temperatures. Stable in neutral, slightly acid, or basic media. Sublimes at high temperatures and when heated, especially at high temperatures in acid or basic media, hydrolyzes to hydroxyatrazine (2-hydroxy-4-ethylamino-6-isopropylamino-S-triazine), which has no herbicidal activity... 

Li and Felbeck (1972) reported that the half-lives for atrazine at 25 °C and pH 4 with and without fulvic acid (2%) were 1.73 and 244 d, respectively. The hydrolysis half-lives in a 5 mg/L fulvic acid solution and 25 °C at pH values of 2.9, 4.5, 6.0, and 7.0 were 34.8, 174, 398, and 742 d, respectively. The only product identified was 2-(ethylamino)-4-hydroxy-6-isopropylamino-5-triazine (Khan, 1978). The primary degradative pathway appears to be chemical (i.e., hydrolysis) rather than microbial (Armstrong et al., 1967 Best and Weber, 1974 Gormley and Spalding, 1979 Geller, 1980 Lowder and Weber, 1982 Skipper et al, 1967). 

In the presence of hydroxy or perhydroxy radicals generated from Fenton s reagent, atrazine undergoes oxidative dealkylation in aqueous solutions (Kaufman and Kearney, 1970). Major products identified by GC/MS included deisopropylatrazine (2-chloro-4-ethylamino-6-amino-s-triazine), 2-chloro-4-amino-6-isopropylamino-5-triazine, and a dealkylated dealkylatrazine (2-chloro-4,6-diamino-s-triazine) (Kaufman and Kearney, 1970). 

The primary ozonation by-products of atrazine (15 mg/L) in natural surface water and synthetic water were deethylatrazine, deisopropylatrazine, 2-chloro-4,6-diamino-s-triazine, a deisopropylatrazine amide (4-acetamido-4-amino-6-chloro-5-triazine), 2-amino-4-hydroxy-6-isopropylamino-5-triazine, and an unknown compound. The types of compounds formed were pH dependent. At high pH, low alkalinity, or in the presence of hydrogen peroxide, hydroxyl radicals formed from ozone yielded 5-triazine hydroxy analogs via hydrolysis of the Cl-Cl bond. At low pH and low alkalinity, which minimized the production of hydroxy radicals, dealkylated atrazine and an amide were the primary byproducts formed (Adams and Randtke, 1992). 

When prometryn in aqueous solution was exposed to UV light for 3 h, the herbicide was completely converted to hydroxypropazine. Irradiation of soil suspensions containing prometryn was found to be more resistant to photodecomposition. About 75% of the applied amount was converted to hydroxypropazine after 72 h of exposure (Khan, 1982). The UV (A = 253.7 nm) photolysis of prometryn in water, methanol, ethanol, /i-butanol, and benzene yielded 2-methylthio-4,6-bis(isopropylamino)-s-triazine. At wavelengths >300 nm, photodegradation was not observed (Pape and Zabik, 1970). Khan and Gamble (1983) also studied the UV irradiation (A = 253.7 nm) of prometryn in distilled water and dissolved humic substances. In distilled water, 2-hydroxy-4,6-bis(isopropylamino)-5-triazine and 4,6-bis(isopropylamino)-5-triazine formed as major products. 

CASRN 139-40-2 molecular formula CgHieClNs FW 241.37 Chemical/Physical. The hydrolysis half-lives of propazine in O.lM-HCl, buffer at pH 5.0, and O.lM-NaOH solutions at 20 °C were 7.7, 83, and 5.1 d, respectively. Propazine degraded to 2-hydroxy-4,6-bis(isopropylamino)-l,3,5-triazine (Burkhard and Guth, 1981). 

The sediment concentrations of anthropogenic compounds in the cove were somewhat less variable than upstream this probably reflects the greater bottom uniformity of the cove. Fewer of the plant s compounds were detected in sediment from the channel where the cove leads into the brackish river (Point 18, Figure 1). Found at this location were various phenols (no. 28, 30a, 30b, 31, 33, 38, 39), di-t-butyl-benzoqui-none (no. 57), 3,5-di-t-butyl-4-hydroxy-benzaldehyde (no. 35), three benzotriazoles (no. 6, 10, 12), 4,4 -dichloro-3(trifluoromethyl) carbanilide (no. 77), and 2-chloro-4,6-bis-isopropylamino-s-triazine (no. 14). The only compounds from the plant detected in the sediment sample from the brackish river (Point 19) were the two high molecular weight benzotriazoles (no. 10 and 12) and methyl 3-(3 ,5 -di-t-butyl-4 -hydroxphenyl) propionate (no. 46). 

Bei Einsatz von z. B. 3,5-Dimethyl-l-(imino-isopropylamino-methyl)-pyrazo]/ai-Brom-aceto-phenon erhalt man infolge Hydrolyse des nicht isolierten 2-(3,5-Dimethyl-pyrazolo)-l-isopro-pyl-4-phenyl-im idazols 2-Hydroxy-1 - isopropyl-4 -phenyl- imidazol (51 %)105 ... 

Shimabukuro et al. (1966) identified 2-chloro-4-amino-6-isopropylamino-i-triazine (G-30033) as a major metabolite in shoots of mature pea plants. These results indicated that a second mechanism for tolerance to atrazine existed in some moderately susceptible plants. Later, Shimabukuro (1967a) was able to demonstrate that atrazine could be metabolized independently in both roots and shoots of young pea plants to 2-chloro-4-amino-6-isopropylamino-.t-triazine. This metabolite was much less phytotoxic than the parent compound. The metabolism of atrazine in resistant com and sorghum, in intermediately susceptible pea, and in highly susceptible wheat was reported by Shimabukuro (1967b). This study revealed two possible pathways for metabolism of atrazine in higher plants. All species studied were able to metabolize atrazine by TV-deal kyI ation of either of the two alkyl groups present. Com and wheat that contain the cyclic hydroxyamate (2,4-dihydroxy-7-methoxy-l,4-benzoxazine-3-one) also metabolized atrazine by conversion to hydroxy-atrazine (G-34048). Subsequent metabolism was postulated to be by conversion to more polar compounds. 

N1 - BUTYRANILIDE, 3 -ACETYL-9 -(2-HYDROXY-3-( ISOPROPYLAMINO >PROPOXY)-, HONOHYOROCHLORIDE, (+-)-... 

Atenolol is 4-/2-hydroxy-3-/(l-methylethyl)-amino/-propoxy/-benzenacetamide and is also known as 2-/p-/2-hydroxy-3-(isopropylamino)propoxy/phe-nyl/acetamide or l-p-carbamoylmethylphenoxy-3-iso-propylamino-2-propanol. 

Thereafter, the filtrate was evaporated to dryness in vacuo and the residue was taken up in alcohol. The crystalline precipitate which separated out after some standing was separated by vacuum filtration and washed with alcohol. After recrystallization from 90% alcohol, 61 g (83.2% of theory) of l-(3,5-dihydroxyphenyl)-l-hydroxy-2-isopropylamino-ethane sulfate, MP 202° to 203°C, was obtained. 

A solution of 100 g (1.7 mols) of isopropylamine in 60 cc of water was stirred into a solution of 4-hydroxyphenoxypropylene oxide. After the exothermic reaction has subsided, the reaction mixture was heated for two hours at 60°C. Thereafter, the aqueous ethanol was distilled off, and the solid residue was dissolved in aqueous hydrochloric acid comprising more than the theoretical stoichiometric molar equivalent of hydrochloric acid. The aqueous acid solution was extracted with ether and was then made alkaline with sodium hydroxide, whereby a solid crystalline precipitate was formed which was filtered off and dried over phosphorus pentoxide. The product was l,l-(4 -hydroxyphenoxy)-2-hydroxy-3-isopropylamino-propane. Its hydrochloride had a melting point of 166°C to 169°C. 

Hydroxy-1,5-naphthyridin-2( I //i-one 5-oxide 4-Hydroxy-3-nitro-l,5-naphthyridin-2(17/)-one 2-Iodo-1,5-naphthyridine 4-Iodo-1,5-naphthyridine 4-Isopropylamino- 1,5-naphthyridine 1-oxide 2-Isopropyl-6-methoxy-1,5-naphthyridine-... 

Hexaphenyl-2,6-naphthyridine 3-Hexyl-2,6-naphthyridine 3-Hexyl-2,6-naphthyridine 2-oxide 3-Hydroxy-2,6-naphthyridin-1 (2//)-one l-Isopropoxy-2,6-naphthyridi n-3-amine 3-Isopropoxy-2,6-naphthyridi n-1 -amine l-Isopropylamino-2,6-naphthyridin-3-amine l-Methoxy-4-methyl-2,6-naphthyridin-3-amine l-Methoxy-2,6-naphthyridin-3-amine... 

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