4-Hydroxyphenoxypropylene oxide

A solution of 100 g (1.7 mols) of isopropylamine in 60 cc of water was stirred into a solution of 4-hydroxyphenoxypropylene oxide. After the exothermic reaction has subsided, the reaction mixture was heated for two hours at 60Thereafter, the aqueous ethanol was distilled off, and the solid residue was dissolved in aqueous hydrochloric acid comprising more than the theoretical stoichiometric molar equivalent of hydrochloric acid. The aqueous acid solution was extracted with ether and was then made alkaline with sodium hydroxide, whereby a solid crystalline precipitate was formed which was filtered off and dried over phosphorus pentoxide. The product was 1,1 -(4 -hvdroxvphenoxv)-2-hvdroxv-3-isopropylamino-pro-pane. Its hydrochloride had a melting point of 166°Cto 169°C. 

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