8-Hydroxy-2’-deoxyguanosine brain

Production of ROS, factors involved in the aging process (Finkel and Holbrook, 2000), is elevated in AD brain and may be an important cause of AD (Martins et al., 1986). Elevated levels of oxicUzed hpids (lipid peroxidation, maloncUaldehyde, 4-hydroxynonenal) (Markesbery and Carney, 1999), proteins (advanced glycation end product mocUfications, tyrosine nitration) (Good et al., 1996 Takeda et al., 1998), and nucleic acids (8-hydroxy-deoxyguanosine) have been documented in AD brains (Lyras et al., 1997). Mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex... 

NMDA receptor-mediated oxidative damage also occurs in HD. The caudate nucleus of brain from HD patients has increased levels of 8-hydroxy-2-deoxyguanosine in nuclear DNA (Browne et al., 1997). This observation is... 

Lin LH, Cao S,Yu L,Cui J, Hamilton WJ, Liu PK (2000) Up-regulation of base excision repair activity for 8-hydroxy-2 -deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion. J Neurochem 74 1098-105... 

In PD, the accelerated metabolism of dopamine by monoamine-oxidase-B may result in excessive ROS formation. A role for oxidative stress in PD was demonstrated by marked increases in 8-hydroxy-2 -deoxyguanosine, a hydroxyl radical-damaged guanine nucleotide. Several markers of lipid peroxidation were also found to be significantly increased in PD brain regions (Mariani et al.,... 

Sanchez-Ramos, J., E. Overvik and B. Ames. (1994) A marker of oxyradical-mediated DNA damage (8-hydroxy-2 -deoxyguanosine) is increased in nigrostriatum of Parkinson s disease brain. Neurodegen. 3 197-204... 

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