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Gene delivery systems hydrogels

Recently, other approaches and modifications of HA for gene delivery applications have been investigated. Among the most interesting ones are mixed chitosan-hyaluronan based gene delivery systems [68-70] and PEG-HA photocrosslinked hydrogels [71]. HA has also been used to improve the biocompatibility of branched PEI via covalent conjugation [72],... [Pg.145]

Li, Z Ning, WWJ etc. Controlled gene delivery system based on thermosensitive biodegradable hydrogel. Pharmacol Res, 2003, 20, 884-888. [Pg.43]

Hydrogels prepared via homogeneous esterification of dextran with unsaturated carboxylic acids are advanced polysaccharide-based products useful for drug delivery systems and protective encapsulants, e.g. of viruses used in gene therapy [173]. Very promising in this regard is the dextran maleic acid monoester [174], which can be obtained by conversion of dextran in DMF/LiCl with the maleic anhydride in the presence of TEA. The DS of the products can be easily controlled with the amount of anhydride applied but... [Pg.230]

A cyelodextrin-based supramolecular hydrogel system with eationic co-polymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier. Biodegradable triblock copolymers of metho3gr-poly(ethylene glycol)-Z)-poly(E-caprolactone)-Z)-poly[2-(dimethylamino)ethyl methacrylate]... [Pg.441]

H.T. Ta, C.R. Dass, I. Larson, P.E Choong, and D.E. Dunstan, A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy, Biomaterials, 30 (27), 4815-4823,2009. [Pg.291]

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Gene delivery

Gene delivery systems

Hydrogel delivery systems

Hydrogels systems

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