Hydrogel matrices, properties

However, some negative effects of the combination of CyDs and polysaccharide on the rectal drug delivery were reported. Lin et al. [38] demonstrated that the mixture of (3-CyD and hydroxypropylmethylcellulose (HPMC) markedly reduced the in vivo bioavailability of acetaminophen from both aqueous solution and hydrogels. Not only the lower partition coefficient but also the higher hydrophilic property of the (3-CyD complex and the higher viscosity of HPMC hydrogel matrix might be responsible for the decrease in the in vitro permeation rate and depression of in vivo rectal absorption of acetaminophen. 

The kinetic equation of motion of a hydrogel matrix is available in the frame of biphasic models [2,3] and for simple cases it is possible to obtain the explicit time dependence of the spatially distributed strain of the gel [4-7, 9]. To obtain the relevant properties of the PVME actuator, it is necessary to know the material constants that define the kinetics of... 

Turturro, M., Christenson, M., Larson, , and Papavasihou, G. (2012). Matrix metalloproteinase (MMP) sensitive PEG diacrylate (PEGDA) hydrogels with spatial variations in matrix properties direct vascular cell invasion. Journal of Tissue Engineering and Regenerative Medicine, 6,302. 

Liao, H. M., Munoz-Pinto, D., Qu, X. et al. 2008. Influence of hydrogel mechanical properties and mesh size on vocal fold fibroblast extracellular matrix production and phenotype. Acta Biomater 4 1161-71. 

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