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Rectal drug delivery

Chitosan has also been found to be beneficial in formulation development of delivery systems for local or systemic administration of drug through the rectal route. Chitosan microspheres encapsulating diclofenac sodium incorporated in hydrogels have been designed for efficient rectal administration [126]. Quaternized derivative of chitosan. [Pg.45]


Breimer, D.D., et al. 1985. Rate controlled rectal drug delivery. In Rate control in drug therapy, eds. L.F. Prescott, and W.S. Nimmo, 54. Edinburgh Churchill Livingstone. [Pg.145]

However, some negative effects of the combination of CyDs and polysaccharide on the rectal drug delivery were reported. Lin et al. [38] demonstrated that the mixture of (3-CyD and hydroxypropylmethylcellulose (HPMC) markedly reduced the in vivo bioavailability of acetaminophen from both aqueous solution and hydrogels. Not only the lower partition coefficient but also the higher hydrophilic property of the (3-CyD complex and the higher viscosity of HPMC hydrogel matrix might be responsible for the decrease in the in vitro permeation rate and depression of in vivo rectal absorption of acetaminophen. [Pg.154]

Yamamoto, A., and S. Muranishi. 1997. Rectal drug delivery systems—Improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification. [Pg.172]

Miyazaki, S., et al. 1995. Thermally gelling poloxamine Synperonic T908 solution as a vehicle for rectal drug delivery. Biol Pharm Bull 18 1151. [Pg.172]

Miyazaki, S., Suisha, F., Kawasaki, N., Shirakawa, M., Yamatoya, K., and Attwood, D. (1998),Thermally reversible xyloglucan gels as vehicles for rectal drug delivery,/. Controlled Release, 56,75-83. [Pg.311]

Bile salts were also used for the enhancement of drug absorption, but several studies indicated severe damage due to their use in rectal drug delivery. Sodium tauro-24, 25-dihydrofusidate (STDHF) had a positive effect on the availability of cefoxitin, vasopres-sine, and insulin in rats. ... [Pg.16]

De Leede, L.G.J. Rate-Controlled and Site-Specified Rectal Drug Delivery Ph.D. Thesis State University of Leiden Leiden, The Netherlands, 1983. [Pg.1103]

FUTURE OF RECTAL DRUG DELIVERY Market Potential... [Pg.1308]

Other semi-liquid or liquid preparations can be used rectally (gel, enemas). Rectal drug delivery should not be overlooked in certain therapeutic situations, when oral and parenteral routes are not available, or when the child is unconscious (e.g. postoperative), vomiting or on continuous suction. The absorption is usually rapid and may avoid first-pass metabolism. [Pg.67]

Miyazaki S, Suisha F, Kawasaki N, Shirakawa M, Yamatoya K, Attwood D. Thermally reversible xylo-glucan gels as vehicles for rectal drug delivery. Journal of Controlled Release. 1998 56(l) 75-83. [Pg.1410]


See other pages where Rectal drug delivery is mentioned: [Pg.39]    [Pg.791]    [Pg.135]    [Pg.135]    [Pg.141]    [Pg.141]    [Pg.147]    [Pg.148]    [Pg.150]    [Pg.165]    [Pg.67]    [Pg.1301]    [Pg.1308]    [Pg.1309]    [Pg.641]    [Pg.641]    [Pg.1398]    [Pg.39]    [Pg.45]    [Pg.205]    [Pg.1209]    [Pg.1209]   
See also in sourсe #XX -- [ Pg.618 ]




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