Hydrogel blends

An advantage of radiochemical induced cross-linking is the possibility to combine polymers with different properties. For that purpose, the polymers were separately dissolved in water. The solutions were mixed and irradiated. (Gottlieb et al. 2005) describes the synthesis of temperature-sensitive hydrogel blends of PVME (as thermo-sensitive polymer) and the radiation-cross-linkable polymer PVP (a polymer that is applied in pharmaceutics). The experiments show that the gelation dose of the blend is between the gelation doses of the two pure polymers. 

Zuidema JM, Pap MM et al (2010) Fabrication and characterization of tunable polysaccharide hydrogel blends for neural repair. Acta Biomater 7(4) 1634—1643... 

Mazzitelli S., Pagano C., Giusepponi D., Nastruzzi C., Perioli L. (2013). Hydrogel blends with adjustable properties as patches for transdermal delivery, 454, 47-57. 

Na, K., Kim, S., Woo, D. G., Sun, B. K., Yang, H. N., Chung, H. M. Park, K. H. (2007a) Combination material delivery of dexamethasone and growth factor in hydrogel blended with hyaluronic acid constructs for neocartilage formation. J... 

Charlesby-Pinner plot of pure poly(vinyl methyl ether) (PVME) (white triangle), pure poly(vinylpyrrolidinone) (PVP) (black triangle), and a 1 1 mixture (black circle electron beam white circle y-irradiation) s corresponds to the sol fraction and D to the radiation dose. (From Gottlieb, R., Schmidt, T., Arndt, K., Synthesis of temperature-sensitive hydrogel blends by high-energy irradiation. Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 2005,236,371-376. With permission.)... 

Gottlieb, R., Schmidt, T, Arndt, K., Synthesis of temperature-sensitive hydrogel blends by high-energy irradiation. Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 2005,236,371-376. 

Abad, L., Relieve, L. S., AraruUa, C. T, Dela Rosa, A. M., Properties of radiation synthesized PVP-kappa carrageenan hydrogel blends. Radiation Physics and Chemistry 2003,68,901-908. 

Tranquilan-Aranilla, C., Yoshii, F., Dela Rosa, A. M., Makuuchi, K., Kappa-carrageenan-polyethylene oxide hydrogel blends prepared by gamma irradiation. Radiation Physics and Chemistry 1999, 55(2), 127-131. 

Murakami, K., Aoki, H., Nakamura, S. et al. (2009) Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. Biomaterials, 31(1), 83-90. 

Tam, R.Y., Cooke, M.J., Shoichet, M.S., 2012. A covalently modified hydrogel blend of hyaluronan-methyl cellulose with peptides and growth factors influences neural stem/ progenitor cell fate. J. Mater. Chem. 22, 19402—19411. 

Hydrogel blends based on polyacrylic acid and gelatin were evaluated for in vitro and in vivo biodegradation and in vivo release of gentamicin sulphate. The effect of acrylic acid content on degradation kinetics was investigated. Drug concentration was measured in local skin tissue, blood serum, kidney, liver and spleen. 23 refs. INDIA... 

Murakami K, Aoki H, Nakamura S, Nakamura S, Takikawa M, Hanzawa M, Kishimoto S, Hattori H, Tanaka Y, Kiyosawa T, Sato Y, IshUiara M (2010) Hydrogel blends of chitin/... 

Cauich-Rodriguez JV, Deb S, Smith R (1996) Effect of cross-linking agents on the dynamic mechanical properties of hydrogel blends of poly(acrylic acid)-poly(vinyl alcohol-vinyl acetate). Bimnatmals 17 2259—2264... 

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