Hydrocortisone hemisuccinate

Hydrocortisone hemisuccinate Ibuprofen Indomethacin Ketoprofen Mefenamic acid Naproxen Noramidopyrine Oxyphenbutazone Phenylbutazone Piroxicam Sulindac Sulfinpyrazone Tartrazine Tolmetin... 

Synonyms. Cortisol Hemisuccinate Hydrocortisone Hemisuccinate. C25H340s = 462.5 CAS—2203-97-6... 

A good example of consecutive reactions is the degradation of carmethizole (NSC-602668), an experimental cytotoxic agent (Scheme 6S).44 The hydrolysis of hydrocortisone hemisuccinate (Fig. 11)30 and alkaline epimerization followed by hydrolysis of etoposide (Fig. 12)156157 fit this mathematical model even though their degradation pathways are more complex. 

Figure 11. Time course of hydrolysis of hydrocortisone hemisuccinate (pH 6.9, 70°C). (Reproduced from Ref 30 with permission.)...

Another factor affecting drug stability is electrical current. The stability of hydrocortisone hemisuccinate and phosphate esters as their sodium salts was affected by a change in pH that occurred when current was applied during an iontophoresis study.506 Degradation of propranolol hydrochloride in an electrically modulated drug delivery device has been reported.507... 

E. R. Garrett, Prediction of stability in pharmaceutical preparations X. Alkaline hydrolysis of hydrocortisone hemisuccinate, J. Pharm. Sci. 51, 445-450 (1962). 

Hydrocortisone 21-Sodium Succinate. Sodium 17-hydroxycorticosterone 21 -succinate hydrocortisone hemisuccinate sodium salt A-hydro Cort Solu-Cortef Corlan EF-Cortdan Soluble Hycorace Buccalsone Soln-Glyc Intracort Nordicort Saxizon Suxizon 300. C2,ll3J-NaO, mol wt 484.50. C 61.97%. H 6.86%. Na 4.75%. O 26,42%, ROCCHjCHjCOONa where R is the 21-hydrocortisone radical. 133.7 mg of hydrocortisone 21-sodium succinate equals 100 mg of hydrocortisone (free alcohol) Orr et a . J. Clin. Endocrinol. Metab. 15, 763 (1955). 

Other Activities. Picrolichenic acid was successfully used against intermittent fever (Alms 1832 Zopf 1907). Pulvinic acid dilactone has a pronounced cardiotonic activity (Nador et al. 1954), secalonic acid A has a phlogistic activity (Harada et al. 1974) and vulpinic acid an antiinflammatory activity (Foden et al. 1975). Usnic and diffractaic acids have analgesic and antipyretic activities comparable to amino-phenazone, phenylbutazone and hydrocortisone hemisuccinate (Dobrescu et al. 1993 Okuyama et al. 1995). 

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