Modulated drug delivery

McClelland, G.A. and Zentner, GM., Solubility modulated drug delivery system, US Patent 4946686, 1990. 

Sershen S, West J. Implantable, polymeric systems for modulated drug delivery. Adv Drug Deliv Rev. 2002 54 1225-1235. 

Sershen, S. R., Westcott, S. L., Halas, N. J., and West, N. J. (2000), Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery, /. Biomed. Mater. Res., 51, 293-298. 

In addition to traditional dermal and transdermal delivery formulations, such as creams, ointments, gels, and patches, several other systems have been evaluated. In the pharmaceutical semisolid and liquid formulation area,these include sprays, foams, multiple emulsions, microemulsions, liposomal formulations, transfersomes, niosomes, ethosomes, cyclodextrins, glycospheres, dermal membrane structures, and microsponges. Many of these novel systems use vesicles to modulate drug delivery. Novel transdermal... 

Another factor affecting drug stability is electrical current. The stability of hydrocortisone hemisuccinate and phosphate esters as their sodium salts was affected by a change in pH that occurred when current was applied during an iontophoresis study.506 Degradation of propranolol hydrochloride in an electrically modulated drug delivery device has been reported.507... 

Ramanathan, S. and Block, L.H. 2001. The use of chitosan gels as matrices for electrically-modulated drug delivery. J Control Release. 70 109-123. 

Patil, J. S., Kamalapur, M. V., Marapur, S. C., and Kadam, D. V. Ionotropic gelation and polyelectrolyte complexation the novel techniques to design hydrogel particulate, sustained, modulated drug delivery system A review. Digest J. Nanomat. Biostruct. 5(1) (2010) 241-248. 

Da Silva E. R, Sitta D. L. A., Fragal V. H., Cellet T. S. R, Mauricio M. R., Garcia R R, Nakamura C. V. (2014). Covalent Ti02/pectin microspheres with Fe304 nanoparticles for magnetic field-modulated drug delivery. 67,43-52. 

A photothermal modulated drug delivery system in which near IR fight of a specific wavelength can be used to induce the collapse of a polymeric matrix loaded with model drug molecules and proteins was reported by Bikram et al. (2007). 

Ahuja G, Pathak K (2009) Porous carriers for controlled/modulated drug delivery. Indian J Pharm... 

R.P. Shaikh, V. Pillay, Y.E. Choonara, L.C. du Toit, V.M.K. Ndesendo, P. Bawa, S. Coopan, A review of multi-responsive systems for rate-modulated drug delivery, AAPS Pharm Sci Tech, 11 (1), 441-459,2010. 

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