Hydrocortisone erythema treatment

However, not all studies support the belief that urea is an effective penetration promoter.25,58-61 For instance, the latency time to induce erythema was not changed by three-weeks treatment with a moisturizer containing 5% urea62 or by pre-treatment of forearm skin with an aqueous solution of 10% urea.59 Moreover, urea (10%) had a minimal effect on the penetration of hydrocortisone through excised human and guinea pig skin.58 Hydrocortisone acetate was even retarded through hairless mouse skin with increasing concentrations of urea (up to 12%).25... 

Erythema multiforme developed in a 4-year-old girl after treatment with topical aural gentamicin sulfate (0.3%) plus hydrocortisone acetate (1%) prescribed for otorrhea (43). 

The potential topical anti-in ammatory activity of Coriandrum sativum essential oil has been investigated in human subjects. Using a monocentric, double-blind trial, erythema was initiated on the backs of 40 volunteers using ultraviolet B (UVB) radiation. The test areas were subsequently treated under occlusion with a lipolotion containing 0.5% or 1% coriander essential oil for 47 h. Betamethasone valerate and hydrocortisone were used as controls, with the vehicle alone as a placebo. The erythema was measured photometrically after 48 h. The 0.5% coriander essential oil signi cantly reduced the UV-induced erythema in comparison to the placebo but was not as effective as hydrocortisone. A mild anti-in ammatory effect was thus demonstrated that could be used in the concomitant treatment of in ammatory skin diseases (Reuter et al., 2008). 

A 60-year-old women underwent intravenous regional anesthesia with 3 mg/kg of prilocaine 0.5% diluted with saline to a total of 40 ml for surgical treatment of carpal tunnel syndrome and 3 minutes after injection developed severe erythema and edema in the limb below the tourniquet. Intravenous hydrocortisone was started and the tourniquet was released after 20 minutes. All the skin signs disappeared within 1 hour and there were no systemic reactions after release of the tourniquet. A skin prick test later confirmed allergy to prilocaine. 

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