SEARCH Articles Figures Tables A Orientation of water molecules in the hydration layer Clathrate hydrates guest molecules encaged Free-energy barrier for escape of water molecules from protein hydration layer Hydrated molecules, excited Hydrates water molecules Hydration nonpolar molecules Hydration of Nonpolar Molecules Hydration of polar molecules Hydration shell water molecules Polar molecules hydration Polar water molecules hydrates Solvation protonated hydrates, water molecule