Humans variants

The multiple human variants of G-6-PD and the relationship of their kinetic properties to the presence of hemolytic anemia under conditions which closely simulate the erythrocyte internal environment have been elegantly studied by Yoshida (112). This author found that those enzyme variants with significantly reduced physiological activity are those associated with hemolytic anemia. 

Cahill I have a question relating to the human variants. If you have both a photopigment and a photoisomerase that are necessary for the response, you shouldn t be able to get a univariant action spectrum. Is this true I thought you were suggesting the possibihty that the reason the melanopsin knockouts had a subtle effect was that melanopsin was necessary as a photoisomerase. 

Higgins T, Chaykin S, Hammond KB, Humbert JR (1972) Trimethylamine-N-oxide synthesis a human variant. Biochem Med 6 392-3963... 

Homo sapiens (isozyme PGKl [71] mutant pathological variant phosphoglycerate kinase-Uppsala with R206P [66] New Guinea human variant [44]) [1, 17, 19, 27, 40-44, 46, 49, 61, 66, 71, 72]... 

Fu, Y., and Grieninger, G. (1994). Fib420 A normal human variant of fibrinogen with two extended alpha chains. Proc. Natl. Acad. Sci. USA 91, 2625—2628. 

Human, variant of UGT2B11, 82% homologous with UGT2B7... 

In vitro and ex vivo studies of recombinant human variant of the BPI showed strong neutralizing activity against endotoxin and whole gram-negative bacterias (Weiss et al., 1992). 

Tier 1 involves the application of a simplified form of CA. It boils down to calculating the ratio between the exposure concentration of each component and a point estimate from its concentration-effect curve (e.g., the EC10, EC50, or NOEC), and the summation of these ratios. The human variant of this approach is the HI, and... 

Fig. 4. Location of the glycosylation sites on the peptide chain of human variants 1 [74] and 2 [ 117], mouse [121], cow [118], mare, goat [81] and swine [80,120] lactotransferrins (a), mapping not determined solid circles on bars, glycosylated sites heavy bars, non-glycosylated sites. In cow lactotransferrin, glycans are of the oligomannosidic type at positions 233 and 545, of the oligomannosidic or iV-acetyllactosaminic type at positions 368 and 476. Only the glycans of the Af-acetyllactosaminic type at position 476 contain one Af-acetylgalactosamine residue.

Experimental cancers 1. Look for an RER phenotype in the proposed counterpart to the human variant CRC. 

Human plasma kallikrein and human Variants of the first Kunitz domain of 85... 

Todd NV, Morrow J, Doh-Ura K, DeaUer S, O Hare S, FarUng P, Duddy M, Rainov NG (2005) Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease. J Infect 50 394-396... 

The work of Brown and Goldstein got serendipitous support from the discovery, a Japanese veterinarian had made at Kobe University. In 1973, Yoshio Watanabe (1927-2008) noticed incidentally that a rabbit from his colony showed a tenfold increased blood cholesterol level. By appropriate breeding, he managed to establish a strain of rabbits with this characteristic dysregulation. AH of them developed a coronary heart disease, closely resembling its human variant. Thus, suddenly there was an animal model available to investigate familial hypercholesterolemia much better than with the elaborate method of Brown and Goldstein, who had used tissue cultures of skin cells, in lack of sufficient access to human hepatocytes (fiver cells). [360]... 

Ishima, Y, Sawa, T., Kragh-Hansen, U., Miyamoto, Y, Matsushita, S., Akaike, T, and Otagiri, M. (2007). S-nitrosylation of human variant Albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties. J. Pharmacol. Exp. Ther. 320,969-977. 

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