Human Shock Response

It is recommended that flammability always be assessed first, since it is inherently safer to avoid flammable atmospheres than to avoid sources of ignition such as static electricity. If a flammable atmosphere cannot be avoided at all times, the system should be designed to minimize both the probability and consequences of ignition. In this chapter it is assumed that static electricity is the only source of ignition however, in practical situations all sources of ignition such as those described in [ 157] should be evaluated. 

The potential to form a flammable atmosphere is addressed using methods discussed in Chapters 5 and 6. 

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Heat Shock Response in Environmental Toxicology, Human Development, and Aging 447... 

The Human Heat Shock Response Translational Control of the Heat Shock Response... 

Jurivich, D.A., Sistonen, L., Kroes, R.A., Morimoto, R.I. (1992). Effect of sodium salicylate on the human heat shock response. Science 255, 1243-1245. 

An important example of PLP-dependent amino acid decarboxylation is the conversion of histidine into histamine. Histamine is often involved in human allergic responses, e.g. to insect bites or pollens. Stress stimulates the action of the enzyme histidine decarboxylase and histamine is released from mast cells. Topical antihistamine creams are valuable for pain relief, and oral antihistamines are widely prescribed for nasal allergies such as hay fever. Major effects of histamine include dilation of blood vessels, inflammation and swelling of tissues, and narrowing of airways. In serious cases, life-threatening anaphylactic shock may occur, caused by a dramatic fall in blood pressure. 

Liu, A.Y.C, H.J. Bian, L.E. Huang, and Y.K. Lee (1994). Transient cold-shock induces the heat-shock response upon recovery at 37 degrees C in human cells. J. Biol. Chem. 269 14768-14775. 

Kansanen, E., Jyrkkanen, H.K., Volger, O.L., Leinonen, H., Kivela, A.M., Hakkinen, S.K., Woodcock, S.R. et al. 2009b. Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells Identification of heat shock response as the major pathway activated by nitro-oleic acid. 284,33233-33241. 

Allen, G. The Use of a Spinal Analogue to Compare Human Tolerance to Repeated Shocks with Tolerance to Vibration, in AGARD-CP-253, Models and Analogues for the Evaluation of Human Biodynamic Response, Performance and Protection, North Atlantic Treaty Organization, Neuilly sur Seine, France, 1978. 

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