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Human leukocyte antigen, genetic

The inflammatory response in UC is propagated by atypical type 2 helper T cells that produce proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF).7 As discussed previously, a genetic predisposition to UC may partially explain the development of excessive colonic and rectal inflammation. The finding of positive perinuclear antineutrophil cytoplasmic antibodies (pANCA) in association with the human leukocyte antigen (HLA)-DR2 allele in a large percentage of patients with UC supports this theory.4,12... [Pg.282]

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. [Pg.868]

The cause of type 1 diabetes is not fuUy understood. An autoimmune attack (to the /3-cells of the pancreas) may be triggered by reaction to an infection, for example by one of the viruses of the Coxsackie virus family or German measles, although the evidence is inconclusive. Individuals may display genetic vulnerability an observed inherited tendency to develop type 1 diabetes has been traced to particular human leukocyte antigen (HLA) genotypes (the major histocompatibility complex (MHC) in humans is known as the HLA system). Environmental factors can also strongly influence expression of type 1 diabetes. [Pg.47]

A genetic link with human leukocyte antigen (HLA)-DR4 and related allotypes of MHC class II and the T-cell-associated protein protein tyrosine phosphatase N22 (PTPN22). [Pg.220]

Hardy, L., Hansen, J.L., Kushner, J.R, Knlsely, A.S. Neonatal hemochromatosis. Genetic analysis of transferrin-receptoi H-apoferritin, and L-apoferritin loci and of the human leukocyte antigen class I region. Amer. J. Pathol. 1990 137 149-153... [Pg.634]

In 1976 Simon et al reported an association of human leukocyte antigen (HLA)-A3 and HLA-B14 antigens with idiopathic hemochromatosis, which suggested that the HH gene was located near the major histocoinpatibility complex (MHC) on chromosome 6p (short arm of chromosome gj 409,532 genetic studies confirmed linkage of the HH... [Pg.1486]

Two special genetic regions with sufficient sequence variability for identity testing include the human leukocyte antigen (HLA) loci within the major histocompatibility complex (MHC) and the mitochondrial DNA. The HLA loci described in the Transplantation Testing section later in this... [Pg.1540]

Hg is one of the few chemicals which is able to induce loss of tolerance to self-antigens in animals. This effect is human leukocyte antigen (HLA) dependent and has been demonstrated in genetically susceptible strains of rats and mice. Brown-Norway rats injected with Hg chloride (HgCl2) produce antilaminin antibodies, which attack the kidneys, causing an autoimmime glomerulonephritis (Dmet et al. 1994). The... [Pg.180]

Graham RR, Ortmann WA, Langefeld CD et al 2002 Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet 71 543-553... [Pg.117]

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Human leukocyte antigens

Human leukocytes

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